The unlimited proliferation potential of cancer cells requires the maintenance of their telomeres.
This is frequently accomplished by reactivation of telomerase. However, in a significant …

Leiomyosarcoma (LMS) is an aggressive mesenchymal malignancy with few therapeutic
options. The mechanisms underlying LMS development, including clinically actionable genetic …

The alternative lengthening of telomeres (ALT) mechanism allows cancer cells to escape
senescence and apoptosis in the absence of active telomerase. A characteristic feature of this …

Telomere maintenance is a hallmark of cancer as it provides cancer cells with cellular
immortality. A significant fraction of tumors uses the alternative lengthening of telomeres (ALT) …

Background Establishment of telomere maintenance mechanisms is a universal step in
tumor development to achieve replicative immortality. These processes leave molecular …

Background The ends of linear chromosomes, the telomeres, comprise repetitive DNA
sequences in complex with proteins that protects them from being processed by the DNA repair …

Chromothripsis is a recently discovered form of genomic instability, characterized by tens to
hundreds of clustered DNA rearrangements resulting from a single dramatic event. Telomere …

The microscopic analysis of telomere features provides a wealth of information on the
mechanism by which tumor cells maintain their unlimited proliferative potential. Accordingly, the …

Telomere shortening plays an important role in cellular aging and tumor suppression. The
availability of large next-generation sequencing cohorts of matched tumor and control …

Pediatric glioblastoma (pedGBM) represent a highly malignant primary brain tumor with
recurrent mutations in the chromatin remodeler ATRX and the histone variant H3.3 that is …