To ensure the high-fidelity transmission of genetic information, cells have evolved mechanisms
to monitor genome integrity. Cells respond to DNA damage by activating a complex DNA-…

When 18-year-old Jesse Gelsinger died in a gene transfer study at the University of Pennsylvania,
the national spotlight focused on the procedures used to ensure research participants' …

The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …

Species of Clostridium bacteria are notable for their ability to lyse tumor cells growing in
hypoxic environments. We show that an attenuated strain of Clostridium novyi (C. novyi-NT) …

This paper describes a hierarchical estimation framework for the computation of diverse
representations of motion information. The key features of the resulting framework (or family of …

… Dr Hanna has a proprietary interest in the laser delivery system used in this study. None
of the other authors has a proprietary in¬ terest in the companies or materials involved in the …

The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …

Intestinal microbial metabolites are conjectured to affect mucosal integrity through an
incompletely characterized mechanism. Here we showed that microbial-specific indoles regulated …

Chk1 kinase coordinates cell cycle progression and preserves genome integrity. Here, we
show that chemical or genetic ablation of human Chk1 triggered supraphysiological …

Protein–protein interactions (PPIs) execute many fundamental cellular functions and have
served as prime drug targets over the last two decades. Interfering intracellular PPIs with small …