Several hundred microRNAs (miRNAs) have recently been cloned from a wide range of
organisms across phylogeny. Despite the high degree of conservation of miRNAs, their …

Although several lines of evidence support a role for accumulating somatic mitochondrial DNA
(mtDNA) mutations in the etiology of aging, it remains unclear if they are a major cause of …

Using a novel single-molecule PCR approach to quantify the total burden of mitochondrial
DNA (mtDNA) molecules with deletions, we show that a high proportion of individual …

Human mitochondrial DNA (mtDNA) is a 16.5-kb, circular genome essential for the
maintenance of mitochondrial function and is present in multiple copies in most cell types. High …

Researchers in several laboratories have reported a high frequency of homoplasmic
mitochondrial DNA (mtDNA) mutations in human tumors 1, 2, 3, 4, 5, 6. This observation has been …

We have proposed a DNA sequencing method based on hybridization of a DNA fragment to
be sequenced with the complete set of fixed-length oligonucleotides (eg, 4 8 = 65 536 …

Lineage-restricted cells can be reprogrammed to a pluripotent state known as induced
pluripotent stem (iPS) cells through overexpression of 4 transcription factors. iPS cells are similar …

Contrasting the equal contribution of nuclear genetic material from maternal and paternal
sources to offspring, passage of mitochondria, and thus mitochondrial DNA (mtDNA), is …

Using single-cell sequence analysis, we discovered that a high proportion of cells in tissues
as diverse as buccal epithelium and heart muscle contain high proportions of clonal mutant …

We have found that human organs such as colon, lung, and muscle, as well as their derived
tumors, share nearly all mitochondrial hotspot point mutations. Seventeen hotspots, …