Two decades ago, the sequence of the first human genome was published. Since then,
advances in genome technologies have resulted in whole-genome sequencing and microarray-…

Genome-wide association studies (GWASs) have focused primarily on populations of
European descent, but it is essential that diverse populations become better represented. …

Background: Common cancers develop through a multistep process often including inherited
susceptibility. Collaboration among multiple institutions, and funding from multiple sources, …

Importance The clinical management ofBRCA1andBRCA2mutation carriers requires accurate,
prospective cancer risk estimates. Objectives To estimate age-specific risks of breast, …

… leading researcher23, Chris Finan bioinformatician1, Sonia Shah postdoctoral research
fellow24, Karoline B Kuchenbaecker research associate in genetic epidemiology25, Tina Shah …

Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl…

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC),
we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC …

Most common breast cancer susceptibility variants have been identified through genome-wide
association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease 1 . …

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic
variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of …