User profiles for K. Le Cao

Kim-Anh Lê Cao

University of Melbourne
Verified email at unimelb.edu.au
Cited by 12003

[HTML][HTML] mixOmics: An R package for 'omics feature selection and multiple data integration

…, B Gautier, A Singh, KA Lê Cao - PLoS computational …, 2017 - journals.plos.org
… in the Results Section), we found that K − 1 components, where K is the number of classes,
was … However, assessing the performance of a non sparse model with K to K + 2 components …

Multivariate analysis of multiple datasets: a practical guide for chemical ecology

MR Hervé, F Nicolè, KA Lê Cao - Journal of Chemical Ecology, 2018 - Springer
Chemical ecology has strong links with metabolomics, the large-scale study of all metabolites
detectable in a biological sample. Consequently, chemical ecologists are often challenged …

Statistical challenges in longitudinal microbiome data analysis

S Kodikara, S Ellul, KA Lê Cao - Briefings in Bioinformatics, 2022 - academic.oup.com
k-medoids clustering [53], whereby data are allocated into k clusters (similar to … Kim-Anh
Cao is associate professor in Statistical Genomics. Her laboratory focuses on the …

[HTML][HTML] Sparse PLS discriminant analysis: biologically relevant feature selection and graphical displays for multiclass problems

KA Lê Cao, S Boitard, P Besse - BMC bioinformatics, 2011 - Springer
K - 1 (K - 2) dimensions is sufficient to explain the covariance structure of the microarray (SNP)
data. In the following, we only record the classification error rate obtained after K - 1 (K - 2…

A sparse PLS for variable selection when integrating omics data

KA Lê Cao, D Rossouw, C Robert-Granié… - … applications in genetics …, 2008 - degruyter.com
… The first and rather straightforward way is to use k-fold cross validation or leave-one-out
cross validation and compute the prediction error (“RMSEP” see section 1.6.3) in order to …

DIABLO: an integrative approach for identifying key molecular drivers from multi-omics assays

…, F Rohart, M Vacher, SJ Tebbutt, KA Lê Cao - …, 2019 - academic.oup.com
… As the class prediction relies on individual vote from each omics set, DIABLO allows for
some missing datasets X k during the prediction step, as illustrated in the Breast Cancer case …

integrOmics: an R package to unravel relationships between two omics datasets

KA Lê Cao, I González, S Déjean - Bioinformatics, 2009 - academic.oup.com
Motivation: With the availability of many ‘omics’ data, such as transcriptomics, proteomics or
metabolomics, the integrative or joint analysis of multiple datasets from different technology …

Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients

…, JE Connolly, SK Paul, KA Lê Cao… - Science translational …, 2015 - science.org
In animals, immunomodulatory dendritic cells (DCs) exposed to autoantigen can suppress
experimental arthritis in an antigen-specific manner. In rheumatoid arthritis (RA), disease-…

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

…, MS Taylor, NJ Bokil, KA Le Cao… - Proceedings of the …, 2012 - National Acad Sciences
Evolutionary change in gene expression is generally considered to be a major driver of
phenotypic differences between species. We investigated innate immune diversification by …

[HTML][HTML] Sparse canonical methods for biological data integration: application to a cross-platform study

KA Lê Cao, PGP Martin, C Robert-Granié, P Besse - BMC bioinformatics, 2009 - Springer
… We focus on two-block data matrices denoted X(n × p) and Y (n × q), where the p variables
x j and q variables y k are of two types and measured on the same samples or individuals n, …