The evolutionary significance of polyploidy

Y Van de Peer, E Mizrachi, K Marchal - Nature Reviews Genetics, 2017 - nature.com
… Nevertheless, if we believe the correlation between many of the WGDs in plants and the K–Pg
extinction to be real, the majority of the WGDs in plants seem to represent a unique event, …

Advantages and limitations of current network inference methods

R De Smet, K Marchal - Nature Reviews Microbiology, 2010 - nature.com
Network inference, which is the reconstruction of biological networks from high-throughput
data, can provide valuable information about the regulation of gene expression in cells. …

Computational approaches to identify promoters and cis-regulatory elements in plant genomes

S Rombauts, K Florquin, M Lescot, K Marchal… - Plant …, 2003 - academic.oup.com
The identification of promoters and their regulatory elements is one of the major challenges
in bioinformatics and integrates comparative, structural, and functional genomics. Many …

PlantCARE, a database of plant cis-acting regulatory elements and a portal to tools for in silico analysis of promoter sequences

M Lescot, P Déhais, G Thijs, K Marchal… - Nucleic acids …, 2002 - academic.oup.com
PlantCARE is a database of plant cis-acting regulatory elements, enhancers and repressors.
Regulatory elements are represented by positional matrices, consensus sequencesand …

A higher-order background model improves the detection of promoter regulatory elements by Gibbs sampling

G Thijs, M Lescot, K Marchal, S Rombauts… - …, 2001 - academic.oup.com
Motivation: Transcriptome analysis allows detection and clustering of genes that are coexpressed
under various biological circumstances. Under the assumption that coregulated genes …

A Gibbs sampling method to detect over-represented motifs in the upstream regions of co-expressed genes

G Thijs, K Marchal, M Lescot, S Rombauts… - Proceedings of the fifth …, 2001 - dl.acm.org
Microarray experiments can reveal useful information on the transcriptional regulation. We try
to find regulatory elements in the region upstream of translation start of coexpressed genes…

[HTML][HTML] SynTReN: a generator of synthetic gene expression data for design and analysis of structure learning algorithms

…, H Ma, A Verschoren, B De Moor, K Marchal - BMC …, 2006 - Springer
… Examples of interaction functions for one activator and different combinations of the kinetic
parameters K and h. Parameter tuples (K,h) are (0.05,1); (0.15,1); (0.5,1); (10,2); (10,5); (100,1…

Strong antimicrobial activity of Lactobacillus rhamnosus GG against Salmonella typhimurium is due to accumulation of lactic acid

…, TLA Verhoeven, J Desair, K Marchal… - FEMS microbiology …, 2006 - academic.oup.com
Spent culture supernatant (SCS) of the probiotic Lactobacillus rhamnosus GG had been
reported to exert antibacterial activity against Salmonella typhimurium. However, the chemical …

Brominated Furanones Inhibit Biofilm Formation by Salmonella enterica Serovar Typhimurium

…, D De Coster, TL Verhoeven, K Marchal… - Applied and …, 2008 - Am Soc Microbiol
Salmonella enterica serovar Typhimurium is a main cause of bacterial food-borne diseases.
As Salmonella can form biofilms in which it is better protected against antimicrobial agents …

[PDF][PDF] Obg and membrane depolarization are part of a microbial bet-hedging strategy that leads to antibiotic tolerance

…, JE Michiels, Q Fu, CC David, AC Fierro, K Marchal… - Molecular cell, 2015 - cell.com
Within bacterial populations, a small fraction of persister cells is transiently capable of surviving
exposure to lethal doses of antibiotics. As a bet-hedging strategy, persistence levels are …