User profiles for K. McJunkin
Katherine McJunkinNIDDK Intramural Research Program Verified email at nih.gov Cited by 3081 |
miR-221 overexpression contributes to liver tumorigenesis
P Pineau, S Volinia, K McJunkin… - Proceedings of the …, 2010 - National Acad Sciences
… K.-1 cells were transfected with vector expressing miR-221, miR-222, or empty vector,
and protein levels were checked by Western blotting with the indicated antibodies. One …
and protein levels were checked by Western blotting with the indicated antibodies. One …
Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia
… K over-represented shRNAs from the screen, in comparison with the full shRNA library. We
used values of K … by a Fisher's exact test for any value of K (P >0.05 in all cases for each gene)…
used values of K … by a Fisher's exact test for any value of K (P >0.05 in all cases for each gene)…
In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer
R Rudalska, D Dauch, T Longerich, K McJunkin… - Nature medicine, 2014 - nature.com
In solid tumors, resistance to therapy inevitably develops upon treatment with cytotoxic drugs
or molecularly targeted therapies. Here, we describe a system that enables pooled shRNA …
or molecularly targeted therapies. Here, we describe a system that enables pooled shRNA …
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi
Short hairpin RNAs (shRNAs) are versatile tools for analyzing loss-of-function phenotypes
in vitro and in vivo 1 . However, their use for studying genes involved in proliferation and …
in vitro and in vivo 1 . However, their use for studying genes involved in proliferation and …
[PDF][PDF] Functional identification of optimized RNAi triggers using a massively parallel sensor assay
… to nonscoring shRNAs and flanking mRNA regions, the nucleotide composition of potent
guide strands shows many significant positional biases (p < 0.01, Pearson’sc2 test with Šidá k …
guide strands shows many significant positional biases (p < 0.01, Pearson’sc2 test with Šidá k …
Recent advances in understanding microRNA function and regulation in C. elegans
K Kotagama, K McJunkin - Seminars in Cell & Developmental Biology, 2023 - Elsevier
MicroRNAs (miRNAs) were first discovered in C. elegans as essential post-transcriptional
regulators of gene expression. Since their initial discovery, miRNAs have been implicated in …
regulators of gene expression. Since their initial discovery, miRNAs have been implicated in …
A pipeline for the generation of shRNA transgenic mice
RNA interference (RNAi) is an extremely effective tool for studying gene function in almost
all metazoan and eukaryotic model systems. RNAi in mice, through the expression of short …
all metazoan and eukaryotic model systems. RNAi in mice, through the expression of short …
Tissue-specific and reversible RNA interference in transgenic mice
Genetically engineered mice provide powerful tools for understanding mammalian gene
function. These models traditionally rely on gene overexpression from transgenes or targeted, …
function. These models traditionally rely on gene overexpression from transgenes or targeted, …
CRISPR screening strategies for microRNA target identification
B Yang, K McJunkin - The FEBS Journal, 2020 - Wiley Online Library
Identifying microRNA (miRNA) target genes remains a major challenge in understanding
the roles miRNAs play in gene regulation. Furthermore, understanding which miRNA–target …
the roles miRNAs play in gene regulation. Furthermore, understanding which miRNA–target …
A microRNA family exerts maternal control on sex determination in C. elegans
K McJunkin, V Ambros - Genes & development, 2017 - genesdev.cshlp.org
Gene expression in early animal embryogenesis is in large part controlled post-transcriptionally.
Maternally contributed microRNAs may therefore play important roles in early …
Maternally contributed microRNAs may therefore play important roles in early …