Humanity is currently facing the challenge of two devastating pandemics caused by two very
different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which …

The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves.
The first was associated with a mix of SARS-CoV-2 lineages, while the second and third …

Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating
conditions for substantial evolutionary changes to the virus 1 , 2 . Here we describe a newly …

Background The SARS-CoV-2 omicron variant of concern was identified in South Africa in
November, 2021, and was associated with an increase in COVID-19 cases. We aimed to …

Continued uncontrolled transmission of the severe acute respiratory syndrome-related
coronavirus 2 (SARS-CoV-2) in many parts of the world is creating the conditions for significant …

We provide two methods for monitoring reinfection trends in routine surveillance data to identify
signatures of changes in reinfection risk and apply these approaches to data from South …

The Centre for the AIDS Program of Research in South Africa (CAPRISA) 004 trial assessed
the effectiveness and safety of a 1% vaginal gel formulation of tenofovir, a nucleotide …

On 5 March 2020, South Africa recorded its first case of imported COVID-19. Since then,
cases in South Africa have increased exponentially with significant community transmission. A …

Identifying the specific genetic characteristics of successfully transmitted variants may prove
central to the development of effective vaccine and microbicide interventions. Although …

The first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in South
Africa was identified on 5 March 2020, and by 26 March the country was in full lockdown (…