Li-Fraumeni syndrome (LFS) is an autosomal dominantly inherited condition caused by
germline mutations of the TP53 tumor suppressor gene encoding p53, a transcription factor …

… The finding that the concomitant overexpression of MDM2 and either p53 or RB confers
worse prognosis suggests that one p53-independent oncogenic function of MDM2 may be to …

… Among individuals exposed to radiation who developed NMSC as SN1 in this analysis, one
in five developed an invasive neoplasm within 15 years—an incidence almost twice that of …

… Renal involvement is one of the main determinants of poor prognosis of systemic lupus …
NGAL is one of the most robustly expressed proteins in the kidney following ischemic or …

… One impressive finding of our study is the marked increase in urinary NGAL levels up to 3 …
One possibility is that the kinetics and specificity of the molecule may be different from those …

BACKGROUND Undifferentiated systemic autoinflammatory diseases (USAIDs) present
diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine …

Objective To uniquely classify children with microscopic polyangiitis (MPA), to describe their
demographic characteristics, presenting clinical features, and initial treatments in …

… To confirm that conformational differences may explain the remaining discrepancies, we
selected one candidate antigen (CD244) that was present in the microarray analysis and absent …

… For example, both mice and humans harboring a germline inactivating mutation in one
allele of the p53 gene develop tumors very early in life and at dramatically high frequencies ( …

Lupus nephritis (LN) is among the main determinants of poor prognosis in systemic lupus
erythematosus (SLE). The objective of this study was to 1) isolate and identify proteins …