A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

…, DS Evans, S Metrustry, K Panoutsopoulou… - Annals of the …, 2014 - ard.bmj.com
Objectives Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component.
To identify novel loci associated with hip OA we performed a meta-analysis of genome…

The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource

…, D Osumi-Sutherland, K Panoutsopoulou… - Nucleic acids …, 2023 - academic.oup.com
The NHGRI-EBI GWAS Catalog ( www.ebi.ac.uk/gwas ) is a FAIR knowledgebase providing
detailed, structured, standardised and interoperable genome-wide association study (GWAS…

Advances in osteoarthritis genetics

K Panoutsopoulou, E Zeggini - Journal of medical genetics, 2013 - jmg.bmj.com
Osteoarthritis (OA), the most common form of arthritis, is a highly debilitating disease of the
joints and can lead to severe pain and disability. There is no cure for OA. Current treatments …

In search of low-frequency and rare variants affecting complex traits

K Panoutsopoulou, I Tachmazidou… - Human molecular …, 2013 - academic.oup.com
The allelic architecture of complex traits is likely to be underpinned by a combination of
multiple common frequency and rare variants. Targeted genotyping arrays and next-generation …

Genome-wide associations for birth weight and correlations with adult disease

…, P Kovacs, M Atalay, SM Willems, K Panoutsopoulou… - Nature, 2016 - nature.com
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in
observational studies is reproducibly associated with future risk of adult metabolic diseases …

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

…, BM Shields, BA Knight, JF Chai, K Panoutsopoulou… - Nature …, 2019 - nature.com
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …

[HTML][HTML] The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study

…, M Mueller-Nurasyid, IM Nolte, K Panoutsopoulou… - PLoS …, 2015 - journals.plos.org
Genome-wide association studies (GWAS) have identified more than 100 genetic variants
contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHR …

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

…, N Nishida, WER Ollier, K Panoutsopoulou… - Annals of the …, 2011 - ard.bmj.com
Objectives Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial
morbidity and disability, particularly in older people. It is characterised by changes in …

[HTML][HTML] Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

…, AJ Oldehinkel, K Pahkala, K Panoutsopoulou… - PLoS …, 2020 - journals.plos.org
The genetic background of childhood body mass index (BMI), and the extent to which the
well-known associations of childhood BMI with adult diseases are explained by shared genetic …

[PDF][PDF] A variant in MCF2L is associated with osteoarthritis

AG Day-Williams, L Southam, K Panoutsopoulou… - The American Journal of …, 2011 - cell.com
Osteoarthritis (OA) is a prevalent, heritable degenerative joint disease with a substantial
public health impact. We used a 1000-Genomes-Project-based imputation in a genome-wide …