Abnormalities in human pluripotent cells due to reprogramming mechanisms

…, M Hariharan, JR Nery, R Castanon, K Sabatini… - Nature, 2014 - nature.com
Human pluripotent stem cells hold potential for regenerative medicine, but available cell types
have significant limitations. Although embryonic stem cells (ES cells) from in vitro fertilized …

[HTML][HTML] Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions

…, FS Boscolo, GK Wambua, HL Schultheisz, K Sabatini… - PloS one, 2015 - journals.plos.org
The self-renewal and differentiation capacities of human pluripotent stem cells (hPSCs)
make them a promising source of material for cell transplantation therapy, drug development, …

Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease

…, DP Pizzo, KK Nelson, K Sabatini… - Proceedings of the …, 2016 - National Acad Sciences
Trophoblast is the primary epithelial cell type in the placenta, a transient organ required for
proper fetal growth and development. Different trophoblast subtypes are responsible for gas/…

A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics

…, CI Chavarria, I Friedrich Ben-Nun, Y Li, K Sabatini… - Elife, 2015 - elifesciences.org
10.7554/eLife.07103.001 Comparative genomics studies in primates are restricted due to
our limited access to samples. In order to gain better insight into the genetic processes that …

[HTML][HTML] Interfacial behavior of cholesterol, ergosterol, and lanosterol in mixtures with DPPC and DMPC

K Sabatini, JP Mattila, PKJ Kinnunen - Biophysical journal, 2008 - cell.com
Binary mixtures of cholesterol, ergosterol, and lanosterol with phosphatidylcholines differing
in the length of the saturated acyl chains, viz 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (…

Primate cell fusion disentangles gene regulatory divergence in neurodevelopment

…, D Sun, F Birey, SJ Yoon, Y Miura, K Sabatini… - Nature, 2021 - nature.com
Among primates, humans display a unique trajectory of development that is responsible for
the many traits specific to our species. However, the inaccessibility of primary human and …

[HTML][HTML] Stage-specific regulation of the WNT/β-catenin pathway enhances differentiation of hESCs into hepatocytes

…, S Chen, CC To, S Mora-Castilla, K Sabatini… - Journal of …, 2016 - Elsevier
Background & Aims Hepatocytes differentiated from human embryonic stem cells (hESCs)
have the potential to overcome the shortage of primary hepatocytes for clinical use and drug …

[HTML][HTML] Oxidized phospholipids as potential molecular targets for antimicrobial peptides

JP Mattila, K Sabatini, PKJ Kinnunen - Biochimica et Biophysica Acta (BBA) …, 2008 - Elsevier
… Instead, compared to DMPC the values for K SV were further decreased in the presence of
DMPG and PoxnoPC containing LUVs. Similar changes in K SV values were evident also for …

[HTML][HTML] Oxidized phospholipids induce phase separation in lipid vesicles

FM Megli, L Russo, K Sabatini - FEBS letters, 2005 - Elsevier
The thermal behaviour of phospholipid multilamellar vesicles (MLV) made of various molar
percentages of DPPC and LPPC, containing also oxidized LPPC (LPPCox), was studied by …

Spontaneous Single-Copy Loss of TP53 in Human Embryonic Stem Cells Markedly Increases Cell Proliferation and Survival

H Amir, T Touboul, K Sabatini, D Chhabra… - Stem Cells, 2017 - academic.oup.com
Genomic aberrations have been identified in many human pluripotent stem cell (hPSC)
cultures. Commonly observed duplications in portions of chromosomes 12p and 17q have been …