The DNA-binding protein PRDM9 has a critical role in specifying meiotic recombination
hotspots in mice and apes, but it appears to be absent from other vertebrate species, including …

Background Predisposition to complex diseases is explained in part by genetic variation,
and complex diseases are frequently comorbid, consistent with pleiotropic genetic variation …

In recent years, surfaces are being engineered to make their surface texture more suitable
to their function. Most of the “engineered surfaces” are manufactured by more than one …

Chimeric antigen receptor T-cell (CAR-T) therapy is a revolutionary cancer treatment modality
where a patient’s own T cells are collected and engineered ex vivo to express a chimeric …

Background: Transnasal endoscopic repair has become the treatment of choice for most
anterior cranial and all sphenoid sinus breaches. The aim of this paper is to evaluate the results …

Background: Ide-cel received regulatory approval for the treatment of patients with RRMM
after≥ 4 prior lines of therapy based on the results of the pivotal KarMMa trial in which …

Introduction. Recent FDA approval of idecabtagene vicleucel (ide-cel), a chimeric antigen
receptor (CAR) T-cell therapy for relapsed/refractory multiple myeloma (RRMM), offers …

Idecabtagene vicleucel (ide-cel) the first FDA-approved gene therapy for relapsed refractory
multiple myeloma (RRMM). However, its administration presents challenges in logistical …

Background: Liquid biopsies have emerged as convenient alternative diagnostic methods
to invasive biopsies, by evaluating disease-specific biomarkers and monitoring the disease …

In recent times Cloud Computing has become an accessible technology which makes it
possible to provide online services to end user by the network of remote servers. With the …