User profiles for K. Slotkin

R. Keith Slotkin

Donald Danforth Plant Science Center & University of Missouri Division of Biological …
Verified email at danforthcenter.org
Cited by 8854

Transposable elements and the epigenetic regulation of the genome

RK Slotkin, R Martienssen - Nature reviews genetics, 2007 - nature.com
Overlapping epigenetic mechanisms have evolved in eukaryotic cells to silence the expression
and mobility of transposable elements (TEs). Owing to their ability to recruit the silencing …

Non-canonical RNA-directed DNA methylation

D Cuerda-Gil, RK Slotkin - Nature plants, 2016 - nature.com
Small RNA-directed DNA methylation (RdDM) has been extensively studied in plants,
resulting in a deep understanding of a major ‘canonical RdDM’mechanism. However, current …

The first rule of plant transposable element silencing: location, location, location

MJ Sigman, RK Slotkin - The Plant Cell, 2016 - academic.oup.com
Transposable elements (TEs) are mobile units of DNA that comprise large portions of plant
genomes. Besides creating mutations via transposition and contributing to genome size, TEs …

[PDF][PDF] Extracellular vesicle and particle biomarkers define multiple human cancers

…, LH Wexler, SR Ambati, AJ Chou, EK Slotkin… - Cell, 2020 - cell.com
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection.
We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in …

[HTML][HTML] Epigenetic reprogramming and small RNA silencing of transposable elements in pollen

RK Slotkin, M Vaughn, F Borges, M Tanurdžić… - Cell, 2009 - cell.com
… To determine the developmental timing of TE pollen expression, we stained developing
flowers from GT7390 for GUS activity (Figure 2K). Anthers at floral stages 8–9 did not stain, while …

Control of female gamete formation by a small RNA pathway in Arabidopsis

…, E Demesa-Arévalo, D Autran, D Grimanelli, RK Slotkin… - Nature, 2010 - nature.com
In the ovules of most sexual flowering plants female gametogenesis is initiated from a single
surviving gametic cell, the functional megaspore, formed after meiosis of the somatically …

The initiation of epigenetic silencing of active transposable elements is triggered by RDR6 and 21-22 nucleotide small interfering RNAs

…, D Fultz, C DeFraia, EN Thomas, RK Slotkin - Plant …, 2013 - academic.oup.com
Transposable elements ( TEs ) are mobile fragments of DNA that are repressed in both
plant and animal genomes through the epigenetic inheritance of repressed chromatin and …

[HTML][HTML] Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets

…, K Thornton, PA Meyers, LH Wexler, EK Slotkin… - Nature …, 2022 - nature.com
The genetic, biologic, and clinical heterogeneity of sarcomas poses a challenge for the
identification of therapeutic targets, clinical research, and advancing patient care. Because there …

[HTML][HTML] Kismeth: analyzer of plant methylation states through bisulfite sequencing

E Gruntman, Y Qi, RK Slotkin, T Roeder… - BMC …, 2008 - Springer
Background There is great interest in probing the temporal and spatial patterns of cytosine
methylation states in genomes of a variety of organisms. It is hoped that this will shed light on …

ARGONAUTE 6 bridges transposable element m RNA‐derived si RNA s to the establishment of DNA methylation

…, SG Choudury, EN Thomas, RK Slotkin - The EMBO …, 2015 - embopress.org
… R Keith Slotkin 1 … We detect increased CHH methylation of both TAS3a in wt Col and the
Athila6A TSS in ddm1 (Fig 5K), demonstrating that RDR6-RdDM has its greatest effect in the …