Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency
Chitosan-DNA nanoparticles were prepared using a complex coacervation process. The
important parameters for the nanoparticle synthesis were investigated, including the …
important parameters for the nanoparticle synthesis were investigated, including the …
Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy
Food allergy is a common and often fatal disease with no effective treatment. We describe
here a new immunoprophylactic strategy using oral allergen-gene immunization to modulate …
here a new immunoprophylactic strategy using oral allergen-gene immunization to modulate …
Biomaterials for stem cell differentiation
…, G Mapili, K Erickson, S Taqvi, K Roy - Advanced drug delivery …, 2008 - Elsevier
The promise of cellular therapy lies in the repair of damaged organs and tissues in vivo as
well as generating tissue constructs in vitro for subsequent transplantation. Unfortunately, the …
well as generating tissue constructs in vitro for subsequent transplantation. Unfortunately, the …
Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation
…, GP Dasmahapatra, EA Sausville, KK Roy - Molecular cancer …, 2003 - AACR
Perifosine is a novel po bioavailable alkylphospholipid. Perifosine has displayed significant
antiproliferative activity in vitro and in vivo in several human tumor model systems and has …
antiproliferative activity in vitro and in vivo in several human tumor model systems and has …
A digital micro‐mirror device‐based system for the microfabrication of complex, spatially patterned tissue engineering scaffolds
Our ability to create precise, pre‐designed, spatially patterned biochemical and physical
microenvironments inside polymer scaffolds could provide a powerful tool in studying …
microenvironments inside polymer scaffolds could provide a powerful tool in studying …
Mammalian cells preferentially internalize hydrogel nanodiscs over nanorods and use shape-specific uptake mechanisms
Size, surface charge, and material compositions are known to influence cell uptake of
nanoparticles. However, the effect of particle geometry, ie, the interplay between nanoscale shape …
nanoparticles. However, the effect of particle geometry, ie, the interplay between nanoscale shape …
Function and regulation of the divisome for mitochondrial fission
Mitochondria form dynamic networks in the cell that are balanced by the flux of iterative fusion
and fission events of the organelles. It is now appreciated that mitochondrial fission also …
and fission events of the organelles. It is now appreciated that mitochondrial fission also …
Designer nanoparticles: incorporating size, shape and triggered release into nanoscale drug carriers
Importance of the field: Although significant progress has been made in delivering therapeutic
agents through micro and nanocarriers, precise control over in vivo biodistribution and …
agents through micro and nanocarriers, precise control over in vivo biodistribution and …
Nanoimprint lithography based fabrication of shape-specific, enzymatically-triggered smart nanoparticles
Our ability to precisely manipulate size, shape and composition of nanoscale carriers is
essential for controlling their in-vivo transport, bio-distribution and drug release mechanism. …
essential for controlling their in-vivo transport, bio-distribution and drug release mechanism. …
NADPH oxidases and cancer
K Roy, Y Wu, JL Meitzler, A Juhasz, H Liu… - Clinical …, 2015 - portlandpress.com
The mechanism by which reactive oxygen species (ROS) are produced by tumour cells
remained incompletely understood until the discovery over the last 15 years of the family of …
remained incompletely understood until the discovery over the last 15 years of the family of …