Early-onset Alzheimer’s disease (EOAD) is a rare but particularly devastating form of AD.
Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same …

Background Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost
importance. Although genetic studies have identified AD-associated SNPs in APOE and …

Purpose of Review In this review, we highlight recent advances in the human genetics of
frontotemporal dementia (FTD). In addition to providing a broad survey of genes implicated in …

Importance Late-onset Alzheimer disease (AD), the most common form of dementia, places
a large burden on families and society. Although epidemiological and clinical evidence …

Background Converging evidence suggests that immune-mediated dysfunction plays an
important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic studies …

Background Clinical, pathological and genetic overlap between sporadic frontotemporal
dementia (FTD), Alzheimer's disease (AD) and Parkinson's disease (PD) has been suggested; …

A major sex difference in Alzheimer’s disease (AD) is that men with the disease die earlier
than do women. In aging and preclinical AD, men also show more cognitive deficits. Here, we …

Microglia play a critical but poorly understood role in promoting white-matter homeostasis.
In this review, we leverage advances in human genetics and mouse models of …

Corticobasal degeneration (CBD), progressive supranuclear palsy (PSP) and a subset of
frontotemporal dementia (FTD) are neurodegenerative disorders characterized by tau …

There is an urgent need for identifying nondemented individuals at the highest risk of
progressing to Alzheimer’s disease (AD) dementia. Here, we evaluated whether a recently …