… Zhang and L. Hou: Association of genetic polymorphisms in STAT1 gene with increased
risk of … Wynshaw-Boris and L. Hennighausen: Stat5a is mandatory for adult mammary gland …

Hedgehog (HH)/GLI signaling plays a critical role in epidermal development and basal cell
carcinoma. Here, we provide evidence that epidermal growth factor receptor (EGFR) …

BACKGROUND AND AIMS: The transcription factor signal transducer and activator of
transcription 3 (Stat3) has been considered to promote progression and metastasis of intestinal …

STAT3 is considered to play an oncogenic role in several malignancies including lung cancer;
consequently, targeting STAT3 is currently proposed as therapeutic intervention. Here we …

A role for Hedgehog (Hh) signalling in the development of colorectal cancer (CRC) has
been proposed. In CRC and other solid tumours, Hh ligands are upregulated; however, a …

… 1D, d, h, and l) was associated with elevated serum levels of alanine aminotransferase (ALT)
and alkaline phosphatase (ALP) as indicators of liver injury (Fig. 1E). In contrast, …

The mammary gland is composed of a complex cellular hierarchy with unusual postnatal
plasticity. The identities of stem/progenitor cell populations, as well as tumour-initiating cells …

BACKGROUND & AIMS: Signal transducer and activator of transcription 3 (Stat3) is the main
mediator of interleukin-6–type cytokine signaling required for hepatocyte proliferation and …

10.7554/eLife.23382.001 The gene desert upstream of the MYC oncogene on chromosome
8q24 contains susceptibility loci for several major forms of human cancer. The region shows …

The structure of the receptor for the fimbriae of Haemophilus influenzae on human oropharyngeal
epithelial cells and erythrocytes was determined in inhibition experiments with various …