User profiles for L. Bullinger
Lars BullingerCharité University Medicine Berlin Verified email at charite.de Cited by 43899 |
Genomics of acute myeloid leukemia diagnosis and pathways
L Bullinger, K Döhner, H Döhner - Journal of clinical oncology, 2017 - ascopubs.org
In recent years, our understanding of the molecular pathogenesis of myeloid neoplasms,
including acute myeloid leukemia (AML), has been greatly advanced by genomics discovery …
including acute myeloid leukemia (AML), has been greatly advanced by genomics discovery …
Genetics of chronic lymphocytic leukemia: genomic aberrations and VH gene mutation status in pathogenesis and clinical course
The genetic characterization of chronic lymphocytic leukemia (CLL) has made significant
progress over the past few years. While conventional cytogenetic analyses only detected …
progress over the past few years. While conventional cytogenetic analyses only detected …
[HTML][HTML] Genomic classification and prognosis in acute myeloid leukemia
Background Recent studies have provided a detailed census of genes that are mutated in
acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity …
acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity …
[HTML][HTML] Genomic aberrations and survival in chronic lymphocytic leukemia
…, E Leupolt, A Kröber, L Bullinger… - … England Journal of …, 2000 - Mass Medical Soc
Background Fluorescence in situ hybridization has improved the detection of genomic
aberrations in chronic lymphocytic leukemia. We used this method to identify chromosomal …
aberrations in chronic lymphocytic leukemia. We used this method to identify chromosomal …
[HTML][HTML] Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
…, S Fröhling, A Corbacioglu, L Bullinger… - … England Journal of …, 2008 - Mass Medical Soc
Background Mutations occur in several genes in cytogenetically normal acute myeloid
leukemia (AML) cells: the nucleophosmin gene (NPM1), the fms-related tyrosine kinase 3 gene (…
leukemia (AML) cells: the nucleophosmin gene (NPM1), the fms-related tyrosine kinase 3 gene (…
[PDF][PDF] MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L
…, AV Krivtsov, Z Feng, N Punt, A Daigle, L Bullinger… - Cancer cell, 2011 - cell.com
The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development
of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) gene. We …
of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) gene. We …
[HTML][HTML] Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia
Background In patients with acute myeloid leukemia (AML), the presence or absence of
recurrent cytogenetic aberrations is used to identify the appropriate therapy. However, the …
recurrent cytogenetic aberrations is used to identify the appropriate therapy. However, the …
[HTML][HTML] Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
Genomic rearrangements are thought to occur progressively during tumor development.
Recent findings, however, suggest an alternative mechanism, involving massive chromosome …
Recent findings, however, suggest an alternative mechanism, involving massive chromosome …
Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene …
…, C Scholl, FG Rücker, A Corbacioglu, L Bullinger… - Blood, 2005 - ashpublications.org
To assess the prognostic relevance of mutations in the NPM1 gene encoding a nucleocytoplasmic
shuttle protein in younger adults with acute myeloid leukemia (AML) and normal …
shuttle protein in younger adults with acute myeloid leukemia (AML) and normal …
Lenalidomide induces ubiquitination and degradation of CK1α in del (5q) MDS
Lenalidomide is a highly effective treatment for myelodysplastic syndrome (MDS) with
deletion of chromosome 5q (del(5q)). Here, we demonstrate that lenalidomide induces the …
deletion of chromosome 5q (del(5q)). Here, we demonstrate that lenalidomide induces the …