[HTML][HTML] Independent component analysis for unraveling the complexity of cancer omics datasets
Independent component analysis (ICA) is a matrix factorization approach where the signals
captured by each individual matrix factors are optimized to become as mutually independent …
captured by each individual matrix factors are optimized to become as mutually independent …
[HTML][HTML] Emerging treatments for malignant pleural mesothelioma: where are we heading?
Malignant pleural mesothelioma (MPM) is an uncommon but aggressive and treatment resistant
neoplasm with low survival rates. In the last years we assisted to an exponential growth …
neoplasm with low survival rates. In the last years we assisted to an exponential growth …
[HTML][HTML] Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy
KHT Paraiso, IV Fedorenko, LP Cantini… - British journal of …, 2010 - nature.com
Background: Resistance to BRAF inhibitors is an emerging problem in the melanoma field.
Strategies to prevent and overcome resistance are urgently required. Methods: The dynamics …
Strategies to prevent and overcome resistance are urgently required. Methods: The dynamics …
[HTML][HTML] The landscape of ALK-rearranged non-small cell lung cancer: A comprehensive review of clinicopathologic, genomic characteristics, and therapeutic …
…, A Lupi, G Pinterpe, C De Filippis, C Felicetti, L Cantini… - Cancers, 2022 - mdpi.com
Simple Summary In recent years, prognosis of non-small cell lung cancer (NSCLC) patients
significantly improved thanks to the introduction of tyrosine kinase inhibitors (TKIs) in clinical …
significantly improved thanks to the introduction of tyrosine kinase inhibitors (TKIs) in clinical …
Outcomes of the SARS-CoV-2 omicron (B. 1.1. 529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the …
…, A Patriarca, C Martinez-Vila, L Cantini… - The Lancet …, 2022 - thelancet.com
Background The omicron (B.1.1.529) variant of SARS-CoV-2 is highly transmissible and
escapes vaccine-induced immunity. We aimed to describe outcomes due to COVID-19 during …
escapes vaccine-induced immunity. We aimed to describe outcomes due to COVID-19 during …
[HTML][HTML] Benchmarking joint multi-omics dimensionality reduction approaches for the study of cancer
High-dimensional multi-omics data are now standard in biology. They can greatly enhance
our understanding of biological systems when effectively integrated. To achieve proper …
our understanding of biological systems when effectively integrated. To achieve proper …
[HTML][HTML] Evaluation of COVID-19 impact on DELAYing diagnostic-therapeutic pathways of lung cancer patients in Italy (COVID-DELAY study): fewer cases and higher …
L Cantini, G Mentrasti, GL Russo, D Signorelli… - ESMO open, 2022 - Elsevier
Introduction COVID-19 has disrupted the global health care system since March 2020. Lung
cancer (LC) patients (pts) represent a vulnerable population highly affected by the pandemic…
cancer (LC) patients (pts) represent a vulnerable population highly affected by the pandemic…
Prevalence and impact of COVID-19 sequelae on treatment and survival of patients with cancer who recovered from SARS-CoV-2 infection: evidence from the …
Background The medium-term and long-term impact of COVID-19 in patients with cancer is
not yet known. In this study, we aimed to describe the prevalence of COVID-19 sequelae and …
not yet known. In this study, we aimed to describe the prevalence of COVID-19 sequelae and …
[HTML][HTML] Detection of gene communities in multi-networks reveals cancer drivers
We propose a new multi-network-based strategy to integrate different layers of genomic
information and use them in a coordinate way to identify driving cancer genes. The multi-…
information and use them in a coordinate way to identify driving cancer genes. The multi-…
Nonabelian bundle gerbes, their differential geometry and gauge theory
Bundle gerbes are a higher version of line bundles, we present nonabelian bundle gerbes
as a higher version of principal bundles. Connection, curving, curvature and gauge …
as a higher version of principal bundles. Connection, curving, curvature and gauge …