… Of these signals, the well-characterized tetrapeptide KDEL sequence (where K is lysine,
D is aspartate, E is glutamate and L is leucine) is present at the carboxyl terminus of many …

A variety of quality control mechanisms operate in the endoplasmic reticulum and in downstream
compartments of the secretory pathway to ensure the fidelity and regulation of protein …

… Molinari and members of the Ellgaard and Ruddock groups for critical reading of the manuscript.
The authors also thank the Swiss National Research Foundation, ETH Zurich, Biocenter …

The process of ‘quality control’ in the endoplasmic reticulum (ER) involves a variety of
mechanisms that collectively ensure that only correctly folded, assembled and modified proteins …

… and Ellgaard, L., unpublished data) are partially oxidized in vivo. Although, as pointed out
above, a redox equilibrium between PDIs and the glutathione redox buffer in the ER cannot be …

Cell entry of Simian Virus 40 (SV40) involves caveolar/lipid raft-mediated endocytosis,
vesicular transport to the endoplasmic reticulum (ER), translocation into the cytosol, and import …

… At OD 600 = 0.6 expression was induced with 0.4 mM isopropyl l-d-galactopyranoside. The
cells were harvested after 4 h, and the pellet was resuspended in 30 ml buffer A (25 mM Tris⋅…

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visit http://covercontest.embo.org and find out how you can take part in The EMBO Journal …

Our concept of how disulfides form in proteins entering the secretory pathway has changed
dramatically in recent years. The discovery of endoplasmic reticulum (ER) oxidoreductin 1 (…

The thiol-disulfide oxidoreductase ERp57 is a soluble protein of the endoplasmic reticulum
and the closest known homologue of protein disulfide isomerase. The protein interacts with …