Analysis of shared heritability in common disorders of the brain
…, H Hakonarson, WA Kukull, LA Farrer… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …
[HTML][HTML] Adherence in internet interventions for anxiety and depression: systematic review
Background: Open access websites which deliver cognitive and behavioral interventions for
anxiety and depression are characterised by poor adherence. We need to understand more …
anxiety and depression are characterised by poor adherence. We need to understand more …
Internet-based cognitive behavioral therapy for depression: a systematic review and individual patient data network meta-analysis
…, L Bücker, LB Sheeber, L Warmerdam, L Farrer… - JAMA …, 2021 - jamanetwork.com
Importance Personalized treatment choices would increase the effectiveness of internet-based
cognitive behavioral therapy (iCBT) for depression to the extent that patients differ in …
cognitive behavioral therapy (iCBT) for depression to the extent that patients differ in …
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis
Objective. —To examine more closely the association between apolipoprotein E (APOE)
genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and …
genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and …
Complement factor H polymorphism and age-related macular degeneration
…, KJ Abel, A Manning, C Panhuysen, LA Farrer - Science, 2005 - science.org
Age-related macular degeneration (AMD) is a common, late-onset, and complex trait with
multiple risk factors. Concentrating on a region harboring a locus for AMD on 1q25-31, the …
multiple risk factors. Concentrating on a region harboring a locus for AMD on 1q25-31, the …
Genome-wide analysis of genetic loci associated with Alzheimer disease
Context Genome-wide association studies (GWAS) have recently identified CLU, PICALM,
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the
elderly, with limited therapeutic options. Here we report on a study of >12 million variants, …
elderly, with limited therapeutic options. Here we report on a study of >12 million variants, …
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic
pathways plays a key role in the generation of amyloid β peptide (Aβ) in Alzheimer disease. …
pathways plays a key role in the generation of amyloid β peptide (Aβ) in Alzheimer disease. …
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
…, M Smith, C Janus, Y Zhang, R Aebersold, L Farrer… - Nature, 2000 - nature.com
Nicastrin, a transmembrane glycoprotein, forms high molecular weight complexes with
presenilin 1 and presenilin 2. Suppression of nicastrin expression in Caenorhabditis elegans …
presenilin 1 and presenilin 2. Suppression of nicastrin expression in Caenorhabditis elegans …
Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14
Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with
a very small proportion of early onset pedigrees being associated with mutations in the …
a very small proportion of early onset pedigrees being associated with mutations in the …