Side populations (SP), as defined by Hoechst exclusion in flow cytometry, have been described
a few years ago. While they represent only a small fraction of the whole cell population, …

Purpose An increasing proportion of patients (> 30%) with node-positive breast cancer will
obtain an axillary pathologic complete response after neoadjuvant chemotherapy (NAC). If …

Oxygen-depleted hypoxic regions in the tumour are generally resistant to therapies 1 . Although
nanocarriers have been used to deliver drugs, the targeting ratios have been very low. …

Translational regulation plays a critical role in the control of cell growth and proliferation. A
key player in translational control is eIF4E, the mRNA 5′ cap-binding protein. Aberrant …

Pressure overload induces cardiac growth in the rat, which implies the hypertrophy of cardiac
muscle cells and proliferation of nonmuscle cells. The cardiac cell loss observed in parallel …

… of tdt in buffer containing 2 mmol/L CoCl 2 , 0.5 mmol/L dithiothreitol, 100 mmol/L potassium
cacodylate, 166 mmol/L [ 32 P]dCTP (3000 Ci/mmol), 664 mmol/L dCTP, and 20 U tdt. After …

Magnetic tumor targeting with external magnets is a promising method to increase the
delivery of cytotoxic agents to tumor cells while reducing side effects. However, this approach …

Despite its importance in human cancers, including colorectal cancers (CRC), oncogenic
KRAS has been extremely challenging to target therapeutically. To identify potential …

Background In 2014, breast cancer remains a major cause of mortality worldwide mostly
due to tumor relapse and metastasis. There is currently a great interest in identifying cancer …

Purpose: Although the murine orthologue of glycoprotein nonmetastatic B (GPNMB),
Osteoactivin, promotes breast cancer metastasis in an in vivo mouse model, its importance in …