Osteosarcoma Osteosarcoma, which is most common in people 10 to 30 years of age, is
generally treated with resection and adjuvant chemotherapy. Detection of gene rearrangements…

Sarcomas are a rare and diverse group of tumours that are derived from connective tissues,
including bone, muscle and cartilage. Although there are instances of hereditary …

Rhabdomyosarcoma (RMS) is a malignant tumor of mesenchymal origin thought to arise
from cells committed to a skeletal muscle lineage. With approximately 250 cases diagnosed …

Purpose Adoptive immunotherapy using tumor-infiltrating lymphocytes represents an
effective cancer treatment for patients with metastatic melanoma. The NY-ESO-1 cancer/testis …

Rapamycin and several analogs, such as CCI-779 and RAD001, are currently undergoing
clinical evaluation as anticancer agents. In this study, we show that inhibition of mammalian …

Metastatic cancers, once established, are the primary cause of mortality associated with
cancer. Previously, we used a genomic approach to identify metastasis-associated genes in …

Carney-Stratakis syndrome, an inherited condition predisposing affected individuals to
gastrointestinal stromal tumor (GIST) and paraganglioma, is caused by germline mutations in …

Patients presenting with metastatic rhabdomyosarcoma (RMS), the most common soft-tissue
sarcoma in children, have a very poor clinical prognosis. This is due, in large part, to our …

CD4 + CD25 + regulatory T (T reg ) cells have a crucial role in maintaining immune tolerance.
Mice and humans born lacking T reg cells develop severe autoimmune disease 1 , 2 , and …

Purpose We conducted the first phase 0 clinical trial in oncology of a therapeutic agent
under the Exploratory Investigational New Drug Guidance of the US Food and Drug …