User profiles for L. M Olde Loohuis
Loes Olde LoohuisAssistant professor at UCLA Verified email at mednet.ucla.edu Cited by 9433 |
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide
association study of 41,917 bipolar disorder cases and 371,549 controls of European …
association study of 41,917 bipolar disorder cases and 371,549 controls of European …
Common genetic variants influence human subcortical brain structures
The highly complex structure of the human brain is strongly shaped by genetic influences 1 .
Subcortical brain regions form circuits with cortical areas to coordinate movement 2 , …
Subcortical brain regions form circuits with cortical areas to coordinate movement 2 , …
The genetic architecture of the human cerebral cortex
…, P Najt, S Nakahara, K Nho, LM Olde Loohuis… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological, …
Variations in human cortical surface area and thickness are associated with neurological, …
[HTML][HTML] Polygenic scoring accuracy varies across the genetic ancestry continuum
Polygenic scores (PGSs) have limited portability across different groupings of individuals (for
example, by genetic ancestries and/or social determinants of health), preventing their …
example, by genetic ancestries and/or social determinants of health), preventing their …
Genetic variants associated with longitudinal changes in brain structure across the lifespan
Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …
The relationship between polygenic risk scores and cognition in schizophrenia
…, B Konte, L Lennertz, LM Olde Loohuis… - Schizophrenia …, 2020 - academic.oup.com
Background Cognitive impairment is a clinically important feature of schizophrenia. Polygenic
risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, …
risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, …
[HTML][HTML] Transcriptome analysis in whole blood reveals increased microbial diversity in schizophrenia
The role of the human microbiome in health and disease is increasingly appreciated. We
studied the composition of microbial communities present in blood across 192 individuals, …
studied the composition of microbial communities present in blood across 192 individuals, …
[HTML][HTML] Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia
Schizophrenia is highly heritable, yet its underlying pathophysiology remains largely unknown.
Among the most well-replicated findings in neurobiological studies of schizophrenia are …
Among the most well-replicated findings in neurobiological studies of schizophrenia are …
[HTML][HTML] Dose response of the 16p11. 2 distal copy number variant on intracranial volume and basal ganglia
Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing
neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to eg, autism …
neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to eg, autism …
Genome-wide association study identifies 30 loci associated with bipolar disorder
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …