To be or not to be in the nucleolus

M Carmo-Fonseca, L Mendes-Soares, I Campos - Nature cell biology, 2000 - nature.com
Compartmentalization has long been known to have a key role in regulation of cellular processes.
By keeping enzymes and regulatory complexes in compartments where the delivery of …

The expanding transcriptome: the genome as the 'Book of Sand'

LM Mendes Soares, J Valcárcel - The EMBO Journal, 2006 - embopress.org
The central dogma of molecular biology inspired by classical work in prokaryotic organisms
accounts for only part of the genetic agenda of complex eukaryotes. First, post‐…

Triplet repeats, RNA secondary structure and toxic gain-of-function models for pathogenesis

R Galvão, L Mendes-Soares, J Câmara, I Jaco… - Brain research …, 2001 - Elsevier
Ten years after the discovery of human diseases caused by trinucleotide repeat expansions,
searching for mechanistic links between gene mutation and pathological phenotype …

[HTML][HTML] Mammalian SWI/SNF chromatin remodeling complexes: emerging mechanisms and therapeutic strategies

RC Centore, GJ Sandoval, LMM Soares, C Kadoch… - Trends in Genetics, 2020 - cell.com
Small molecule-based targeting of chromatin regulatory factors has emerged as a promising
therapeutic strategy in recent years. The development and ongoing clinical evaluation of …

Cannabidiol reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia

MA Mori, E Meyer, LM Soares, H Milani… - Progress in Neuro …, 2017 - Elsevier
This study investigated the effects of cannabidiol (CBD), a non-psychotomimetic phytochemical
present in Cannabis sativa, on the cognitive and emotional impairments induced by …

Intron removal requires proofreading of U2AF/3'splice site recognition by DEK

LMM Soares, K Zanier, C Mackereth, M Sattler… - Science, 2006 - science.org
Discrimination between splice sites and similar, nonsplice sequences is essential for correct
intron removal and messenger RNA formation in eukaryotes. The 65- and 35-kD subunits of …

Influence of Vaginal Bacteria and d- and l-Lactic Acid Isomers on Vaginal Extracellular Matrix Metalloproteinase Inducer: Implications for Protection against Upper …

SS Witkin, H Mendes-Soares, IM Linhares, A Jayaram… - MBio, 2013 - Am Soc Microbiol
We evaluated levels of vaginal extracellular matrix metalloproteinase inducer (EMMPRIN)
and matrix metalloproteinase (MMP-8) in vaginal secretions in relation to the composition of …

Protective effects of cannabidiol against hippocampal cell death and cognitive impairment induced by bilateral common carotid artery occlusion in mice

AP Schiavon, LM Soares, JM Bonato, H Milani… - Neurotoxicity …, 2014 - Springer
The present study investigated whether cannabidiol (CBD), a major non-psychoactive
constituent of marijuana, protects against hippocampal neurodegeneration and cognitive deficits …

[HTML][HTML] MMinte: an application for predicting metabolic interactions among the microbial species in a community

H Mendes-Soares, M Mundy, LM Soares, N Chia - BMC bioinformatics, 2016 - Springer
Background The explosive growth of microbiome research has yielded great quantities of
data. These data provide us with many answers, but raise just as many questions. 16S rDNA—…

Rolipram improves cognition, reduces anxiety-and despair-like behaviors and impacts hippocampal neuroplasticity after transient global cerebral ischemia

LM Soares, J De Vry, HWM Steinbusch, H Milani… - Neuroscience, 2016 - Elsevier
Cognitive impairment, anxiety- and depressive-like symptoms are well recognized outcome
of cerebral ischemia in clinical and preclinical settings. Rolipram, a phosphodiesterase-4 (…