Large-scale conformational changes are essential to link protein structures with their
function at the cell and organism scale, but have been elusive both experimentally and …

Droplet-based microfluidics appears as a key emerging technology for the miniaturization
and automation of biochemical assays. In terms of technology, it stands on two basic pillars: …

Manifestations of viral infections can differ between women and men 1 , and marked sex
differences have been described in the course of HIV-1 disease. HIV-1–infected women tend to …

Background A century after its discovery, Chagas disease still represents a major neglected
tropical threat. Accurate diagnostics tools as well as surrogate markers of parasitological …

Resistance training is essential for health and performance and confers many benefits such
as increasing skeletal muscle mass, increasing strength and power output, and improving …

Purpose Thousands of children are living with advanced cancer; yet patient-reported
outcomes (PROs) have rarely been used to describe their experiences. We aimed to describe …

We review recent developments in the estimation of an optimal treatment strategy or regime
from longitudinal data collected in an observational study. We also propose novel methods …

Background Control of cervical cancer in developing countries has been hampered by a
failure to achieve high screening uptake. HPV DNA self-collection could increase screening …

… In addition, with the intention of making the presentation self&contained in a companion
paper in this issue of the journal (Orellana, Rotnitzky and Robins, 2010) we provide proofs of …

We explored the clinical and pathological impact of epidermal growth factor receptor (EGFR)
extracellular domain missense mutations. Retrospective assessment of 260 de novo …