Male-specific fruitless (fru) products (Fru M ) are both necessary and sufficient to "hardwire"
the potential for male courtship behavior into the Drosophila nervous system. Fru M is …

… It involves CG12721, a germline-specific TFIIA-L paralogue, which we name Moonshiner
for its activity under the transcriptional ‘prohibition’ of heterochromatin. Moonshiner interacts …

The repression of transposable elements in eukaryotes often involves their transcriptional
silencing via targeted chromatin modifications. In animal gonads, nuclear Argonaute proteins …

In studying the cellular interactions within complex tissues, it is extremely valuable to be able
to reproducibly and flexibly target transgene expression to restricted subsets of cells. This …

… between SMI-31 (l, left side of picture, ×400) and TPPP/p25 immunopositivity (l, right side of
… Asterisks in j–l indicate the same area in adjacent section. TPPP/p25 and alpha-synuclein (a…

Recently, we isolated from bovine brain a protein, TPPP/p25 and identified as p25, a brain-specific
protein that induced aberrant tubulin assemblies. The primary sequence of this …

Background Male-specific products of the fruitless (fru) gene control the development and
function of neuronal circuits that underlie male-specific behaviors in Drosophila, including …

… Pasierbek, for support, the Monoclonal facility at Max Perutz Labs for monoclonal antibodies,
L. Baumgartner for help with Y2H experiments, and D. Görlich for the CRM1 expression …

Identifying distinct anatomical structures within the brain and developing genetic tools to
target them are fundamental steps for understanding brain function. We hypothesize that …

TPPP/p25 is a brain-specific protein, which induces tubulin polymerization and microtubule (MT)
bundling and is enriched in Lewy bodies characteristic of Parkinson's disease [Tirián et …