User profiles for L. Zhang

Lei Zhang

- Verified email at comp.polyu.edu.hk - Cited by 98571

Linqi Zhang

- Verified email at tsinghua.edu.cn - Cited by 36266

Lin Zhang

- Verified email at tongji.edu.cn - Cited by 12736

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

L Zhang, D Lin, X Sun, U Curth, C Drosten… - Science, 2020 - science.org
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome–coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug …

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

…, Q Sun, Z Ming, L Zhang, J Ge, L Zheng, Y Zhang… - Science, 2020 - science.org
A novel coronavirus [severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2)] outbreak
has caused a global coronavirus disease 2019 (COVID-19) pandemic, resulting in tens …

Reducing environmental risk by improving N management in intensive Chinese agricultural systems

…, XP Chen, SL Zhang, LJ Zhang… - Proceedings of the …, 2009 - National Acad Sciences
Excessive N fertilization in intensive agricultural areas of China has resulted in serious
environmental problems because of atmospheric, soil, and water enrichment with reactive N of …

[HTML][HTML] Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China

L Zhang, F Zhu, L Xie, C Wang, J Wang, R Chen, P Jia… - Annals of oncology, 2020 - Elsevier
Background Cancer patients are regarded as a highly vulnerable group in the current Coronavirus
Disease 2019 (COVID-19) pandemic. To date, the clinical characteristics of COVID-19…

Effect of convalescent plasma therapy on time to clinical improvement in patients with severe and life-threatening COVID-19: a randomized clinical trial

…, H Xu, E Deng, X Zhang, C Li, C Wang, S Su, L Zhang… - Jama, 2020 - jamanetwork.com
Importance Convalescent plasma is a potential therapeutic option for patients with coronavirus
disease 2019 (COVID-19), but further data from randomized clinical trials are needed. …

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

…, Z Zhou, L Zhang, Y Wang, Z Zhang… - Proceedings of the …, 2020 - National Acad Sciences
Currently, there are no approved specific antiviral agents for novel coronavirus disease 2019
(COVID-19). In this study, 10 severe patients confirmed by real-time viral RNA test were …

[HTML][HTML] A trial of lopinavir–ritonavir in adults hospitalized with severe Covid-19

…, J Xiang, T Yu, T Bai, X Xie, L Zhang… - New England journal …, 2020 - Mass Medical Soc
Background No therapeutics have yet been proven effective for the treatment of severe
illness caused by SARS-CoV-2. Methods We conducted a randomized, controlled, open-label …

[HTML][HTML] Human neutralizing antibodies elicited by SARS-CoV-2 infection

…, X Shi, L Liu, J Zhao, X Wang, Z Zhang, L Zhang - Nature, 2020 - nature.com
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) presents a global health emergency that is in urgent …

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

…, Y Qiu, J Wang, Y Liu, Y Wei, T Yu, X Zhang, L Zhang - The lancet, 2020 - thelancet.com
… function damage (ALT 7590 U/L, AST 1445 U/L). Most patients had abnormal myocardial …
abnormal creatine kinase (6280 U/L) and lactate dehydrogenase (20 740 U/L). Seven (7%) …

[HTML][HTML] A pneumonia outbreak associated with a new coronavirus of probable bat origin

P Zhou, XL Yang, XG Wang, B Hu, L Zhang, W Zhang… - nature, 2020 - nature.com
… cross-neutralized by horse anti-SARS-CoV serum (gift from L.-F. Wang) at dilutions of 1:40; …
Zhang and A. Du from the WIV core facility centre for their help with producing transmission …