User profiles for Louise V Wain

Louise V Wain

University of Leicester
Verified email at leicester.ac.uk
Cited by 20905

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

…, TH Mosley, S Seshadri, NRG Shrine, LV Wain… - Nature, 2011 - nature.com
Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …

[HTML][HTML] Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study

…, A Horsley, M Marks, K Poinasamy, LV Wain… - The Lancet …, 2021 - thelancet.com
Background The impact of COVID-19 on physical and mental health and employment after
hospitalisation with acute disease is not well understood. The aim of this study was to …

Genome-wide association study identifies eight loci associated with blood pressure

…, DE Grobbee, NC Onland-Moret, ML Bots, LV Wain… - Nature …, 2009 - nature.com
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …

Chimpanzee reservoirs of pandemic and nonpandemic HIV-1

…, ML Santiago, F Bibollet-Ruche, Y Chen, LV Wain… - Science, 2006 - science.org
Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency
syndrome (AIDS), is a zoonotic infection of staggering proportions and social impact. Yet …

Genome-wide association study identifies five loci associated with lung function

E Repapi, I Sayers, LV Wain, PR Burton, T Johnson… - Nature …, 2010 - nature.com
Pulmonary function measures are heritable traits that predict morbidity and mortality and
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

…, MD Tobin, PB Munroe, GB Ehret, LV Wain… - Nature …, 2017 - nature.com
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease
worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) …

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

LV Wain, GC Verwoert, PF O'reilly, G Shi, T Johnson… - Nature …, 2011 - nature.com
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic
blood pressure (DBP) in Europeans 1, 2, 3. We now report genome-wide association …

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

…, L Song, L Kachuri, MS Artigas, MD Tobin, LV Wain… - Nature …, 2017 - nature.com
Although several lung cancer susceptibility loci have been identified, much of the heritability
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

MS Artigas, DW Loth, LV Wain, SA Gharib, M Obeidat… - Nature …, 2011 - nature.com
Pulmonary function measures reflect respiratory health and are used in the diagnosis of
chronic obstructive pulmonary disease. We tested genome-wide association with forced …

[HTML][HTML] Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in …

LV Wain, N Shrine, S Miller, VE Jackson… - The Lancet …, 2015 - thelancet.com
Background Understanding the genetic basis of airflow obstruction and smoking behaviour
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD). …