A major challenge of biology is understanding the relationship between molecular genetic
variation and variation in quantitative traits, including fitness. This relationship determines our …

The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of
205 sequenced inbred lines, derived to improve our understanding of the effects of naturally …

Determining the genetic architecture of complex traits is challenging because phenotypic
variation arises from interactions between multiple, environmentally sensitive alleles. We …

Primary open angle glaucoma (POAG) is a common late-onset neurodegenerative disease.
Ocular hypertension represents a major risk factor, but POAG etiology remains poorly …

Epistasis—nonlinear genetic interactions between polymorphic loci—is the genetic basis of
canalization and speciation, and epistatic interactions can be used to infer genetic networks …

Recent research has found that the dopamine D4 receptor (DRD4) gene and maternal
insensitivity may interact to predict externalizing behavior in preschoolers. The current study …

This study investigated dopamine receptor genes (DRD2 and DRD4) and maternal sensitivity
as predictors of infant respiratory sinus arrhythmia (RSA) and RSA reactivity, purported …

Understanding how DNA sequence variation is translated into variation for complex
phenotypes has remained elusive but is essential for predicting adaptive evolution, for selecting …

Aggression is an evolutionarily conserved complex behavior essential for survival and the
organization of social hierarchies. With the exception of genetic variants associated with …

Quantitative traits are shaped by networks of pleiotropic genes [1]. To understand the
mechanisms that maintain genetic variation for quantitative traits in natural populations and to …