Until recently, dynein was the least understood of the cytoskeletal motors. However, a
wealth of new structural, mechanistic, and cell biological data is shedding light on how this …

… Author links open overlay panel Philip R Baldwin 1 , Yong Zi Tan 1 2 , Edward T Eng 1 ,
William J Rice 1 , Alex J Noble 1 , Carl J Negro 1 , Michael A Cianfrocco 3 , Clinton S Potter 1 2 , …

The orchestration of mitochondria within the cell represents a critical aspect of cell biology.
At the center of this process is the outer mitochondrial membrane protein, Miro. Miro …

Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant
patients and the leading viral cause of birth defects after congenital infection. The glycoprotein …

Eukaryotic transcription-coupled repair (TCR) is an important and well-conserved sub-pathway
of nucleotide excision repair that preferentially removes DNA lesions from the template …

A mechanistic description of metazoan transcription is essential for understanding the
molecular processes that govern cellular decisions. To provide structural insights into the DNA …

Dicer has a central role in RNA-interference pathways by cleaving double-stranded RNAs (dsRNAs)
to produce small regulatory RNAs. Human Dicer can process long double-stranded …

1 Structural biology is in the midst of a revolution. Instrumentation and software improvements
have allowed for the full realization of cryo-electron microscopy (cryo-EM) as a tool …

… This is a major revision of the model for how Lis1 regulates dynein with important
implications for the biological roles of this ubiquitous and highly conserved dynein regulator. …

Human Cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant
patients and in fetuses following congenital infection. The glycoprotein complexes gH/gL/gO …