Transient receptor potential vanilloid (TRPV) cation channels are polymodal sensors involved
in a variety of physiological processes. TRPV2, a member of the TRPV family, is regulated …

Determining high-resolution structures of biological macromolecules amassing less than
100 kilodaltons (kDa) has been a longstanding goal of the cryo-electron microscopy (cryo-EM) …

Self versus non-self discrimination is a key element of innate and adaptive immunity across
life. In bacteria, CRISPR-Cas and restriction-modification systems recognize non-self nucleic …

Calcium transport plays an important role in regulating mitochondrial physiology and
pathophysiology. The mitochondrial calcium uniporter (MCU) is a calcium-selective ion channel …

Nearly all single-particle cryo-EM structures resolved to better than 4-Å resolution have been
determined using 300-keV transmission electron microscopes (TEMs). We demonstrate …

This paper describes outcomes of the 2019 Cryo-EM Model Challenge. The goals were to (1)
assess the quality of models that can be produced from cryogenic electron microscopy (…

The modulation of ion channel activity by lipids is increasingly recognized as a fundamental
component of cellular signalling. The transient receptor potential mucolipin (TRPML) …

Transient receptor potential vanilloid channel 3 (TRPV3), a member of the thermosensitive
TRP (thermoTRPV) channels, is activated by warm temperatures and serves as a key …

Heme-nitric oxide/oxygen (H-NOX) binding domains are a recently discovered family of
heme-based gas sensor proteins that are conserved across eukaryotes and bacteria. Nitric oxide …

… Dambacher, Worden, Herzik et al. used electron microscopy to solve the structure of the lid
complex in high detail – so that it was almost possible to view individual atoms. This revealed …