The determination of complete genome sequences provides us with an opportunity to describe
and analyze evolution at the comprehensive level of genomes. Here we compare nine …

Outbreaks of multidrug-resistant bacteria present a frequent threat to vulnerable patient
populations in hospitals around the world. Intensive care unit (ICU) patients are particularly …

We show that gene co-expression, which generally provides only a very weak signal for the
prediction of functional interactions, can provide a reliable signal by exploiting evolutionary …

A full description of a protein's function requires knowledge of all partner proteins with which
it specifically associates. From a functional perspective, ‘association’ can mean direct …

Anaerobic ammonium oxidation (anammox) has become a main focus in oceanography
and wastewater treatment 1 , 2 . It is also the nitrogen cycle's major remaining biochemical …

The repeated occurrence of genes in each other’s neighbourhood on genomes has been
shown to indicate a functional association between the proteins they encode. Here we …

Species phylogenies derived from comparisons of single genes are rarely consistent with
each other, due to horizontal gene transfer 1, unrecognized paralogy and highly variable rates …

… We compute the metric matrixM with entries mij = (d2 + d2 - dlj)/2,where dij is the Hamming
distance betweensequences i and and 0 is the center of mass of the support. Sequences are …

… MA Huynen1, … Brunner HG, van Driel MA. From syndrome families to functional genomics.
Nat Rev … Huynen MA, Snel B, van Noort V. Comparative genomics for reliable protein-function …

Background: Walker-Warburg syndrome (WWS) is an autosomal recessive condition
characterised by congenital muscular dystrophy, structural brain defects, and eye malformations. …