… PericakVance et al. also excluded this region in late-onset AD families but identified a … In
1991 Pericak-Vance et al. reported linkage/ association of late-onset AD families to a region of …

Participants with higher psychopathy scores showed reduced activity specifically in the
amygdala during emotional moral decision-making (Figure 1, left). Furthermore, reduced …

Multiple sclerosis (MS) is an idiopathic autoimmune neurodegenerative disease. Like many
common diseases, MS has a genetic component; however, as with most complex diseases, …

AMYOTROPHIC lateral sclerosis (ALS) is a degenerative disorder of motor neurons in the
cortex, brainstem and spinal cord 1,2 . Its cause is unknown and it is uniformly fatal, typically …

Age-related macular degeneration (AMD) is a leading cause of visual impairment and
blindness in the elderly whose etiology remains largely unknown. Previous studies identified …

Some cases of Alzheimer's disease are inherited as an autosomal dominant trait. Genetic
linkage studies have mapped a locus (AD3) associated with susceptibility to a very aggressive …

Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized
by multisystemic vascular dysplasia and recurrent haemorrhage. Linkage for some …

Amyotrophic lateral sclerosis (ALS) is a fatal degenerative motor neuron disorder. Ten percent
of cases are inherited; most involve unidentified genes. We report here 13 mutations in …

Objective. —To examine more closely the association between apolipoprotein E (APOE)
genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and …

The apolipoprotein E type 4 allele (APOE-ε4) is genetically associated with the common late
onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20…