10.7554/eLife.26437.001 Influenza virus’ low replicative fidelity contributes to its capacity for
rapid evolution. Clonal sequencing and fluctuation tests have suggested that the influenza …

Lethal mutagenesis is a broad-spectrum antiviral strategy that exploits the high mutation rate
and low mutational tolerance of many RNA viruses. This approach uses mutagenic drugs to …

Viral hepatitis, caused by hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV),
hepatitis D virus (HDV), or hepatitis E virus (HEV), is a major global public health …

… Pauly demonstrates that Ukrainization faltered because of local resistance, a lack of
resources, and Communist Party anxieties about nationalism and a weakening of Soviet power-a …

Sierra Leone is highly endemic for hepatitis B virus (HBV) infection and thus recommends
three doses of hepatitis B vaccine (HepB3) from 6 weeks of age but does not recommend a …

The population diversity and structure of CRISPR-Cas immunity provides key insights into
virus–host interactions. Here, we examined two geographically and genetically distinct natural …

… After 5 min at room temperature, the sample was placed on a magnetic tube rack (Life
Technologies Corp., Rockville, MD). The liquid portion was removed and discarded according to …

Lethal mutagenesis is a broad-spectrum antiviral strategy that employs mutagenic nucleoside
analogs to exploit the high mutation rate and low mutational tolerance of many RNA …

Detection and quantification of viral nucleic acids are important for diagnosing current viral
infections and monitoring response to antiviral therapy. Automated nucleic acid extraction …

In the 1920s, the Ukrainian Commissariat of Education and a circle of progressive educators
aimed to radically transform the educational system in Ukraine, and, as a consequence, the …