[PDF][PDF] Developmental origin and functional specialization of mast cell subsets

MF Gurish, KF Austen - Immunity, 2012 - cell.com
Mast cells (MCs) are constitutively present in most tissues and a distinct subset of MCs can
also be induced upon host responses to inflammation. The hematopoietic lineage …

The diverse roles of mast cells

MF Gurish, KF Austen - The Journal of experimental medicine, 2001 - rupress.org
In this issue, Matsumoto et al.(1) report that histamine exocytosed from brain mast cells (MCs)
after activation by antigenic cross-linking of the high affinity IgE receptor (FcεRI) acts via Hl …

Mast cells: ontogeny, homing, and recruitment of a unique innate effector cell

MF Gurish, JA Boyce - Journal of Allergy and Clinical Immunology, 2006 - Elsevier
Mast cells (MCs) are found principally in peripheral tissues yet are of bone marrow origin.
Recent studies in mice trace the MC lineage from the common myeloid progenitor through the …

Mast cells: a cellular link between autoantibodies and inflammatory arthritis

DM Lee, DS Friend, MF Gurish, C Benoist, D Mathis… - Science, 2002 - science.org
Previous studies have revealed that autoantibodies, complement components, and Fc receptors
each participate in the pathogenesis of erosive arthritis in K/BxN mice. However, it is not …

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

DA Rao, MF Gurish, JL Marshall, K Slowikowski… - Nature, 2017 - nature.com
CD4 + T cells are central mediators of autoimmune pathology; however, defining their key
effector functions in specific autoimmune diseases remains challenging. Pathogenic CD4 + T …

Heparin is essential for the storage of specific granule proteases in mast cells

DE Humphries, GW Wong, DS Friend, MF Gurish… - Nature, 1999 - nature.com
All mammals produce heparin, a negatively charged glycosaminoglycan that is a major
constituent of the secretory granules of mast cells which are found in the peritoneal cavity and …

Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis

Y Arinobu, H Iwasaki, MF Gurish… - Proceedings of the …, 2005 - National Acad Sciences
Basophils and mast cells, which are selectively endowed with the high-affinity IgE receptor
and mediate a range of adaptive and innate immune responses, have an unknown …

[HTML][HTML] Cooperative and antagonistic interplay between PU. 1 and GATA-2 in the specification of myeloid cell fates

…, RP DeKoter, HJ Lee, ED Smith, DW Lancki, MF Gurish… - Immunity, 2002 - cell.com
PU.1 and GATA transcription factors appear to antagonize each other's function in the
development of distinct lineages of the hematopoietic system. In contrast, we demonstrate that PU.…

Mast cells are an essential hematopoietic component for polyp development

…, SE Erdman, C Restaino, MF Gurish… - Proceedings of the …, 2007 - National Acad Sciences
It is generally agreed that most colon cancers develop from adenomatous polyps, and it is this
fact on which screening strategies are based. Although there is overwhelming evidence to …

Intestinal mast cell progenitors require CD49dβ7 (α4β7 integrin) for tissue-specific homing

MF Gurish, H Tao, JP Abonia, A Arya… - The Journal of …, 2001 - rupress.org
Mast cells (MCs) are centrally important in allergic inflammation of the airways, as well as in
the intestinal immune response to helminth infection. A single lineage of bone marrow (BM)-…