User profiles for M. F. Roitman
Mitchell RoitmanUniversity of Illinois at Chicago Verified email at uic.edu Cited by 7269 |
New insights into the specificity and plasticity of reward and aversion encoding in the mesolimbic system
The mesocorticolimbic system, consisting, at its core, of the ventral tegmental area, the nucleus
accumbens, and medial prefrontal cortex, has historically been investigated primarily for …
accumbens, and medial prefrontal cortex, has historically been investigated primarily for …
Illicit dopamine transients: reconciling actions of abused drugs
DP Covey, MF Roitman, PA Garris - Trends in neurosciences, 2014 - cell.com
Phasic increases in brain dopamine are required for cue-directed reward seeking. Although
compelling within the framework of appetitive behavior, the view that illicit drugs hijack …
compelling within the framework of appetitive behavior, the view that illicit drugs hijack …
Dopamine operates as a subsecond modulator of food seeking
The dopamine projection to the nucleus accumbens has been implicated in behaviors directed
toward the acquisition and consumption of natural rewards. The neurochemical studies …
toward the acquisition and consumption of natural rewards. The neurochemical studies …
Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens
The ability to predict favorable outcomes using environmental cues is an essential part of
learned behavior. Dopamine neurons in the midbrain encode such stimulus-reward …
learned behavior. Dopamine neurons in the midbrain encode such stimulus-reward …
[PDF][PDF] Nucleus accumbens neurons are innately tuned for rewarding and aversive taste stimuli, encode their predictors, and are linked to motor output
MF Roitman, RA Wheeler, RM Carelli - Neuron, 2005 - cell.com
The nucleus accumbens (NAc) is a key component of the brain's reward pathway, yet little is
known of how NAc cells respond to primary rewarding or aversive stimuli. Here, naive rats …
known of how NAc cells respond to primary rewarding or aversive stimuli. Here, naive rats …
Real-time chemical responses in the nucleus accumbens differentiate rewarding and aversive stimuli
MF Roitman, RA Wheeler, RM Wightman… - Nature …, 2008 - nature.com
Rewarding and aversive stimuli evoke very different patterns of behavior and are rapidly
discriminated. Here taste stimuli of opposite hedonic valence evoked opposite patterns of …
discriminated. Here taste stimuli of opposite hedonic valence evoked opposite patterns of …
[HTML][HTML] Parallels and overlap: the integration of homeostatic signals by mesolimbic dopamine neurons
Motivated behaviors are often initiated in response to perturbations of homeostasis. Indeed,
animals and humans have fundamental drives to procure (appetitive behaviors) and …
animals and humans have fundamental drives to procure (appetitive behaviors) and …
[HTML][HTML] Rapid dopamine signaling in the nucleus accumbens during contingent and noncontingent cocaine administration
Cocaine acts as a reinforcer through its pharmacological effects on brain monoaminergic
systems, which, through repeated pairings with environmental stimuli, lead to the development …
systems, which, through repeated pairings with environmental stimuli, lead to the development …
Inhibition of PTP1B by trodusquemine (MSI‐1436) causes fat‐specific weight loss in diet‐induced obese mice
KA Lantz, SGE Hart, SL Planey, MF Roitman… - …, 2010 - Wiley Online Library
Trodusquemine (MSI‐1436) causes rapid and reversible weight loss in genetic models of
obesity. To better predict the potential effects of trodusquemine in the clinic, we investigated …
obesity. To better predict the potential effects of trodusquemine in the clinic, we investigated …
Primary food reward and reward‐predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum
Phasic changes in dopamine activity play a critical role in learning and goal‐directed behavior.
Unpredicted reward and reward‐predictive cues evoke phasic increases in the firing rate …
Unpredicted reward and reward‐predictive cues evoke phasic increases in the firing rate …