Genome-wide association studies (GWAS) and large-scale replication studies have identified
common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial …

Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-specific
characterization of DNAm is needed to understand its role in gene regulation and its …

We carried out a trans-ancestry genome-wide association and replication study of blood
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …

INTRODUCTION Telomeres are DNA-protein complexes located at the end of chromosomes
that protect chromosome ends from degradation and fusion. The DNA component of …

We conducted a case-control study to investigate interindividual variability in susceptibility to
health effects of inorganic arsenic due to arsenic metabolism efficiency, genetic factors, and …

Long non-coding RNA (lncRNA) genes have well-established and important impacts on
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still a …

Alterations in DNA methylation frequently occur in hepatocellular cancer (HCC). We have
previously demonstrated that hypermethylation in candidate genes can be detected in plasma …

Arsenic contamination of drinking water is a major public health issue in many countries,
increasing risk for a wide array of diseases, including cancer. There is inter-individual variation …

Here we show that FTO as an N 6 -methyladenosine (m 6 A) RNA demethylase is degraded
by selective autophagy, which is impaired by low-level arsenic exposure to promote …

Gene co-expression networks capture biologically important patterns in gene expression
data, enabling functional analyses of genes, discovery of biomarkers, and interpretation of …