Since its discovery forty years ago, protein ubiquitination has been an ever-expanding field.
Virtually all biological processes are controlled by the post-translational conjugation of …

Oncogenic mutations in the small GTPase Ras are highly prevalent in cancer, but an
understanding of the vulnerabilities of these cancers is lacking. We undertook a genome-wide …

The E2F family of transcriptional regulators sits at the center of cell cycle gene expression
and plays vital roles in normal and cancer cell cycles. Whereas control of E2Fs by the …

… Thanks to the Emanuele laboratory for feedback and thoughtful discussions related to the
topics covered in this review. Our ongoing work is supported by start-up funds from the …

Cullin-RING ligases (CRLs) represent the largest E3 ubiquitin ligase family in eukaryotes,
and the identification of their substrates is critical to understanding regulation of the proteome. …

The outer kinetochore binds microtubules to control chromosome movement. Outer kinetochore
assembly is restricted to mitosis, whereas the inner kinetochore remains tethered to …

Photodynamic therapy (PDT) requires oxygen to cause tumor damage, yet therapy itself can
deplete or enhance tumor oxygenation. In the present work we measured the PDT-induced …

10.7554/eLife.01630.001 Technological advances have enabled the analysis of cellular
protein and RNA levels with unprecedented depth and sensitivity, allowing for an unbiased re-…

The anaphase-promoting complex/cyclosome (APC/C) is a cell cycle-regulated E3 ubiquitin
ligase that controls the degradation of substrate proteins at mitotic exit and throughout the …

The anaphase promoting complex/cyclosome (APC/C) is an ubiquitin ligase and core
component of the cell-cycle oscillator. During G1 phase, APC/C binds to its substrate receptor …