Two sides of the same coin: Monetary incentives concurrently improve and bias confidence judgments
M Lebreton, S Langdon, MJ Slieker… - Science …, 2018 - science.org
Decisions are accompanied by a feeling of confidence, that is, a belief about the decision
being correct. Confidence accuracy is critical, notably in high-stakes situations such as medical …
being correct. Confidence accuracy is critical, notably in high-stakes situations such as medical …
[HTML][HTML] Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression
Background Epigenetic clocks use DNA methylation (DNAm) levels of specific sets of CpG
dinucleotides to accurately predict individual chronological age. A popular application of …
dinucleotides to accurately predict individual chronological age. A popular application of …
Disease variants alter transcription factor levels and methylation of their binding sites
…, F Van Dijk, M Van Galen, J Bot, RC Slieker… - Nature …, 2017 - nature.com
Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences 1 , 2 . Identification of expression …
experiments to understand their functional consequences 1 , 2 . Identification of expression …
[HTML][HTML] Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
Background Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in
humans remains poorly understood. While DNA methylation at many CpG sites closely …
humans remains poorly understood. While DNA methylation at many CpG sites closely …
DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood
Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm),
underlie the relationship between adverse intrauterine conditions and adult …
underlie the relationship between adverse intrauterine conditions and adult …
[HTML][HTML] Identification of biomarkers for glycaemic deterioration in type 2 diabetes
RC Slieker, LA Donnelly, E Akalestou… - Nature …, 2023 - nature.com
We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing
2,973 individuals across three molecular classes, metabolites, lipids and proteins. …
2,973 individuals across three molecular classes, metabolites, lipids and proteins. …
[HTML][HTML] Blood lipids influence DNA methylation in circulating cells
Background Cells can be primed by external stimuli to obtain a long-term epigenetic memory.
We hypothesize that long-term exposure to elevated blood lipids can prime circulating …
We hypothesize that long-term exposure to elevated blood lipids can prime circulating …
[HTML][HTML] Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study
Aims/hypothesis Five clusters based on clinical characteristics have been suggested as
diabetes subtypes: one autoimmune and four subtypes of type 2 diabetes. In the current study …
diabetes subtypes: one autoimmune and four subtypes of type 2 diabetes. In the current study …
Distinct molecular signatures of clinical clusters in people with type 2 diabetes: an IMI-RHAPSODY study
Type 2 diabetes is a multifactorial disease with multiple underlying aetiologies. To address
this heterogeneity, investigators of a previous study clustered people with diabetes according …
this heterogeneity, investigators of a previous study clustered people with diabetes according …
Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas
Progress in high-throughput metabolic profiling provides unprecedented opportunities to
obtain insights into the effects of drugs on human metabolism. The Biobanking BioMolecular …
obtain insights into the effects of drugs on human metabolism. The Biobanking BioMolecular …