Gene expression profiling of islets from pre-diabetic male Zucker diabetic fatty (ZDF) rats
showed increased expression of hypoxia-related genes, prompting investigation of the vascular …

The molecular mechanisms underlying the sex differences in human muscle morphology and
function remain to be elucidated. The sex differences in the skeletal muscle transcriptome …

To clarify the lineage relationship between cells that express the neural stem cell marker
nestin and endocrine cells of the pancreas, we analyzed offspring of a cross between mice …

Acute fatty acid (FA) exposure potentiates glucose-stimulated insulin secretion in β cells
through metabolic and receptor-mediated effects. We assessed the effect of fatty acids on the …

Aerobic capacity is a strong predictor of all-cause mortality and can influence many complex
traits. To explore the biological basis underlying this connection, we developed via artificial …

The effect of diabetes on the structure and function of insulin receptors was studied in rats 7
d after streptozotocin injection, using solubilized, partially purified receptors from rat hindlimb …

The effect of short-term denervation on the response to insulin was studied in isolated rat
soleus and extensor digitorum longus (EDL) muscles 6 and 24 h after severing one sciatic …

We performed whole-genome sequencing for eight inbred rat strains commonly used in
genetic mapping studies. They are the founders of the NIH heterogeneous stock (HS) outbred …

Objective Caloric restriction (CR) is one extrinsic intervention that can improve metabolic
health, and it shares many phenotypical parallels with intrinsic high cardiorespiratory fitness (…

Skeletal muscle rapidly develops severe insulin resistance following denervation, although
insulin binding is unimpaired. Insulin-stimulated receptor tyrosyl kinase activity was studied …