User profiles for M. L. Szpara

Moriah L. Szpara

Pennsylvania State University
Verified email at psu.edu
Cited by 2335

ICTV Virus Taxonomy Profile: Herpesviridae 2021

…, CA Hartley, ML Szpara… - Journal of General …, 2021 - microbiologyresearch.org
Members of the family Herpesviridae have enveloped, spherical virions with characteristic
complex structures consisting of symmetrical and non-symmetrical components. The linear, …

Impacts of genome-wide analyses on our understanding of human herpesvirus diversity and evolution

DW Renner, ML Szpara - Journal of virology, 2018 - Am Soc Microbiol
… We thank our reviewers, members of the Szpara laboratory, and our many colleagues for …
Renner also helped to produce and continues to support the Szpara laboratory's public open-…

Differentiation of the SH-SY5Y human neuroblastoma cell line

MM Shipley, CA Mangold, ML Szpara - JoVE (Journal of Visualized …, 2016 - jove.com
… To heat-inactivate, warm a 50 ml aliquot of FBS at 56 C for 30 min, inverting every 10 min
(… For example, 50 ml of media takes approximately one hour to fully equilibrate (pH 7, 37 C, 5…

Evolution and diversity in human herpes simplex virus genomes

ML Szpara, D Gatherer, A Ochoa, B Greenbaum… - Journal of …, 2014 - Am Soc Microbiol
Herpes simplex virus 1 (HSV-1) causes a chronic, lifelong infection in >60% of adults. Multiple
recent vaccine trials have failed, with viral diversity likely contributing to these failures. To …

[HTML][HTML] Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

…, JYJ Chung, KJ Chen, HS Bateup, ML Szpara… - Nature …, 2020 - nature.com
… cells at a final concentration of 4 μg/ml (six-well plates). For SeV, cells were infected at 150
hemagglutination units (HAU)/ml. For poly I:C, 2 mg/ml of the stock solution was heated at 50 …

[HTML][HTML] Persistent infection with herpes simplex virus 1 and Alzheimer's disease—a call to study how variability in both virus and host may impact disease

CA Mangold, ML Szpara - Viruses, 2019 - mdpi.com
Increasing attention has focused on the contributions of persistent microbial infections with
the manifestation of disease later in life, including neurodegenerative conditions such as …

Sequence variability in clinical and laboratory isolates of herpes simplex virus 1 reveals new mutations

ML Szpara, L Parsons, LW Enquist - Journal of virology, 2010 - Am Soc Microbiol
Herpes simplex virus 1 (HSV-1) is a well-adapted human pathogen that can invade the
peripheral nervous system and persist there as a lifelong latent infection. Despite their ubiquity, …

[HTML][HTML] A wide extent of inter-strain diversity in virulent and vaccine strains of alphaherpesviruses

ML Szpara, YR Tafuri, L Parsons, SR Shamim… - PLoS …, 2011 - journals.plos.org
Alphaherpesviruses are widespread in the human population, and include herpes simplex
virus 1 (HSV-1) and 2, and varicella zoster virus (VZV). These viral pathogens cause …

A phylogenomic analysis of Marek's disease virus reveals independent paths to virulence in Eurasia and North America

…, M Jenckel, S He, D Kunec, ML Szpara… - Evolutionary …, 2017 - Wiley Online Library
… alignment after inspection of a linear regression between ML tree root-to-tip divergences and
… The impact of the recombinant regions on ML tree topology was minimal, but their removal …

[HTML][HTML] Dermatitis during spaceflight associated with HSV-1 reactivation

SK Mehta, ML Szpara, BV Rooney, DM Diak… - Viruses, 2022 - mdpi.com
… A single peripheral blood sample using an 8.5 mL heparin anti-coagulated tube and a 24
h urine pool were also collected, each mission time point (Figure 1). Only one blood sample …