Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide
deaths, respectively, due largely to broad increased risk for disease and injury 1 , 2 , 3 – …

We used a deeply sequenced dataset of 910 individuals, all of African descent, to construct
a set of DNA sequences that is present in these individuals but missing from the reference …

The African Diaspora in the Western Hemisphere represents one of the largest forced
migrations in history and had a profound impact on genetic diversity in modern populations. To …

Most transcriptome-wide association studies (TWASs) so far focus on European ancestry and
lack diversity. To overcome this limitation, we aggregated genome-wide association study (…

Asthma is a complex disease with striking disparities across racial and ethnic groups.
Despite its relatively high burden, representation of individuals of African ancestry in asthma …

Background Since the onset of the SARS-CoV-2 pandemic, most clinical testing has focused
on RT-PCR 1 . Host epigenome manipulation post coronavirus infection 2 , 3 – 4 suggests …

Background COPD is a heterogeneous disease, but there is little consensus on specific
definitions for COPD subtypes. Unsupervised clustering offers the promise of ‘unbiased’ data-…

Common genetic variants explain less variation in complex phenotypes than inferred from
family-based studies, and there is a debate on the source of this ‘missing heritability’. We …

Many common and rare variants associated with hematologic traits have been discovered
through imputation on large-scale reference panels. However, the majority of genome-wide …

Whole-genome sequencing (WGS) was performed to identify the genetic determinants of
peanut allergy in the LEAP study participants (see the Methods section and Table E1 in this …