The neuropathological hallmarks of Alzheimer disease (AD) include “positive” lesions such
as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial …

Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

Amyloid imaging related abnormalities (ARIA) have now been reported in clinical trials with
multiple therapeutic avenues to lower amyloid-β burden in Alzheimer’s disease (AD). In …

A consensus panel from the United States and Europe was convened recently to update
and revise the 1997 consensus guidelines for the neuropathologic evaluation of Alzheimer's …

We present a practical guide for the implementation of recently revised National Institute on
Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’…

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

Two substrates of insulin-degrading enzyme (IDE), amyloid β-protein (Aβ) and insulin, are
critically important in the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes …

Diverse genetic, epigenetic, and developmental programs drive glioblastoma, an incurable
and poorly understood tumor, but their precise characterization remains challenging. Here, …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the
progressive accumulation in selected neurons of protein inclusions containing α-synuclein and …