The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common
Fund program that catalogs how human cells globally respond to chemical, genetic, and …

Mitogen‐activated protein kinase (MAPK) cascades process a myriad of stimuli received by
cell‐surface receptors and generate precise spatiotemporal guidance for multiple target …

Turnover and exchange of nucleosomal histones and their variants, a process long believed
to be static in post-replicative cells, remains largely unexplored in brain. Here, we describe …

Deregulation of ErbB signaling plays a key role in the progression of multiple human cancers.
To help understand ErbB signaling quantitatively, in this work we combine traditional …

Activation of ErbB receptors by epidermal growth factor (EGF) or heregulin (HRG) determines
distinct cell-fate decisions, although signals propagate through shared pathways. Using …

Western blot data are widely used in quantitative applications such as statistical testing and
mathematical modelling. To ensure accurate quantitation and comparability between …

Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family,
play a vital role in the control of cell migration. Using predictive mathematical modeling, mass …

Following the first CNS Anticancer Drug Discovery and Development Conference, the
speakers from the first 4 sessions and organizers of the conference created this White Paper …

Evidence that some high-impact biomedical results cannot be repeated has stimulated interest
in practices that generate findable, accessible, interoperable, and reusable (FAIR) data. …

Background BRAF V600 inhibitors have offered a new gateway for better treatment of metastatic
melanoma. However, the overall efficacy of BRAF V600 inhibitors has been lower than …