Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
…, T Wu, DC Hawes, VA Zhivich, MR Wyatt… - Nature …, 2017 - nature.com
The CRISPR–Cas9 system has revolutionized gene editing both at single genes and in
multiplexed loss-of-function screens, thus enabling precise genome-scale identification of genes …
multiplexed loss-of-function screens, thus enabling precise genome-scale identification of genes …
Severe knee osteoarthritis: a randomized controlled trial of acupuncture, physiotherapy (supervised exercise) and standard management for patients awaiting knee …
L Williamson, MR Wyatt, K Yein, JTK Melton - Rheumatology, 2007 - academic.oup.com
Objective. To evaluate the effects of standardized western acupuncture and physiotherapy
on pain and functional ability in patients with severe osteoarthritic knee pain awaiting knee …
on pain and functional ability in patients with severe osteoarthritic knee pain awaiting knee …
Prionn: Predicting runtime and io using neural networks
For job allocation decision, current batch schedulers have access to and use only information
on the number of nodes and runtime because it is readily available at submission time …
on the number of nodes and runtime because it is readily available at submission time …
[HTML][HTML] Post–12 Ma deformation in the lower Colorado River corridor, southwestern USA: Implications for diffuse transtension and the Bouse Formation
…, ED Strickland, NM Seymour, MR Wyatt - …, 2020 - pubs.geoscienceworld.org
Structural evidence presented here documents that deformation was ongoing within the
lower Colorado River corridor (southwestern USA) during and after the latest Miocene Epoch, …
lower Colorado River corridor (southwestern USA) during and after the latest Miocene Epoch, …
AI4IO: A suite of AI-based tools for IO-aware scheduling
Traditional workload managers do not have the capacity to consider how IO contention can
increase job runtime and even cause entire resource allocations to be wasted. Whether from …
increase job runtime and even cause entire resource allocations to be wasted. Whether from …
Evolution of debris disks
MC Wyatt - Annu. Rev. Astron. Astrophys., 2008 - annualreviews.org
… The planet's secular perturbations stir material closer to its orbit faster than that further
away (Wyatt 2005b), and for this planet configuration the secular perturbation timescales are …
away (Wyatt 2005b), and for this planet configuration the secular perturbation timescales are …
Is disaggregation possible for HPC cognitive simulation?
Cognitive simulation (CogSim) is an important and emerging workflow for HPC scientific
exploration and scientific machine learning (SciML). One challenging workload for CogSim is …
exploration and scientific machine learning (SciML). One challenging workload for CogSim is …
Using 2D dental geometric morphometrics to identify modern Perognathus and Chaetodipus specimens (Rodentia, Heteromyidae)
The Heteromyidae (pocket mice and kangaroo rats) are a group of extant small rodents
abundant in western North America, as well as in fossil assemblages over the last 20 million …
abundant in western North America, as well as in fossil assemblages over the last 20 million …
Canario: Sounding the alarm on io-related performance degradation
Users interact with High Performance Computing (HPC) machines through batch systems,
which take user job submissions and allocate them to computing resources. While some …
which take user job submissions and allocate them to computing resources. While some …
Apex predator nematodes and meso-predator bacteria consume their basal insect prey through discrete stages of chemical transformations
NC Mucci, KA Jones, M Cao, MR Wyatt, S Foye… - Msystems, 2022 - Am Soc Microbiol
Microbial symbiosis drives physiological processes of higher-order systems, including the
acquisition and consumption of nutrients that support symbiotic partner reproduction. …
acquisition and consumption of nutrients that support symbiotic partner reproduction. …