The interaction between ligands and proteins usually induces changes in protein thermal
stability with modifications in the midpoint denaturation temperature, enthalpy of unfolding, and …

Parkinson's disease is an age-related movement disorder characterized by the presence in
the mid-brain of amyloid deposits of the 140-amino-acid protein AS (α-synuclein). AS …

… Adelin Gustot, María Celej and Vincent Raussens analysed the results. Adelin Gustot, José
Gallea, Rabia Sarroukh… fellow and María Soledad Celej is a research associate at CONICET. …

Autophagy is a fundamental cellular homeostatic mechanism, whereby cells autodigest
parts of their cytoplasm for removal or turnover. Neurodegenerative disorders are associated …

… LC–MS/MS. Table 1 shows psychosine elevated in all brain regions in twitcher mice.
Importantly, brain areas containing the most thioflavin-S-positive aggregates also accumulated the …

… -driven spin diffusion for 20 ms in all cases; the external … corresponding to a maximum t 1
of 5.3 ms, with 128 scans per t 1 … , and the contact time was 1 ms. The spectrum was recorded …

The deposition of fibrillar structures (amyloids) is characteristic of pathological conditions
including Alzheimer's and Parkinson's diseases. The detection of protein deposits and the …

Autophagic dysfunction and protein aggregation have been linked to several neurodegenerative
disorders, but the exact mechanisms and causal connections are not clear and most …

The presence of intraneuronal deposits mainly formed by amyloid fibrils of the presynaptic
protein α-synuclein (AS) is a hallmark of Parkinson disease. Currently, neurotoxicity is …

The stability of proteins and their interactions with other molecules is a topic of special
interest in biochemistry because many cellular processes depend on that. New methods and …