User profiles for M. S. Celej
M Soledad CelejCIQUIBIC (UNC-CONICET)-Fac. de Ciencias Químicas, Universidad Nacional de Córdoba Verified email at mail.fcq.unc.edu.ar Cited by 2055 |
Protein stability induced by ligand binding correlates with changes in protein flexibility
MS Celej, GG Montich, GD Fidelio - Protein science, 2003 - Wiley Online Library
The interaction between ligands and proteins usually induces changes in protein thermal
stability with modifications in the midpoint denaturation temperature, enthalpy of unfolding, and …
stability with modifications in the midpoint denaturation temperature, enthalpy of unfolding, and …
Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure
MS Celej, R Sarroukh, E Goormaghtigh… - Biochemical …, 2012 - portlandpress.com
Parkinson's disease is an age-related movement disorder characterized by the presence in
the mid-brain of amyloid deposits of the 140-amino-acid protein AS (α-synuclein). AS …
the mid-brain of amyloid deposits of the 140-amino-acid protein AS (α-synuclein). AS …
Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease
… Adelin Gustot, María Celej and Vincent Raussens analysed the results. Adelin Gustot, José
Gallea, Rabia Sarroukh… fellow and María Soledad Celej is a research associate at CONICET. …
Gallea, Rabia Sarroukh… fellow and María Soledad Celej is a research associate at CONICET. …
[HTML][HTML] Autophagy down regulates pro-inflammatory mediators in BV2 microglial cells and rescues both LPS and alpha-synuclein induced neuronal cell death
Autophagy is a fundamental cellular homeostatic mechanism, whereby cells autodigest
parts of their cytoplasm for removal or turnover. Neurodegenerative disorders are associated …
parts of their cytoplasm for removal or turnover. Neurodegenerative disorders are associated …
Neuronal inclusions of α‐synuclein contribute to the pathogenesis of Krabbe disease
… LC–MS/MS. Table 1 shows psychosine elevated in all brain regions in twitcher mice.
Importantly, brain areas containing the most thioflavin-S-positive aggregates also accumulated the …
Importantly, brain areas containing the most thioflavin-S-positive aggregates also accumulated the …
Solid-state NMR reveals structural differences between fibrils of wild-type and disease-related A53T mutant α-synuclein
H Heise, MS Celej, S Becker, D Riedel, A Pelah… - Journal of molecular …, 2008 - Elsevier
… -driven spin diffusion for 20 ms in all cases; the external … corresponding to a maximum t 1
of 5.3 ms, with 128 scans per t 1 … , and the contact time was 1 ms. The spectrum was recorded …
of 5.3 ms, with 128 scans per t 1 … , and the contact time was 1 ms. The spectrum was recorded …
[HTML][HTML] Fluorescent N-arylaminonaphthalene sulfonate probes for amyloid aggregation of α-synuclein
MS Celej, EA Jares-Erijman, TM Jovin - Biophysical journal, 2008 - cell.com
The deposition of fibrillar structures (amyloids) is characteristic of pathological conditions
including Alzheimer's and Parkinson's diseases. The detection of protein deposits and the …
including Alzheimer's and Parkinson's diseases. The detection of protein deposits and the …
Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells
Autophagic dysfunction and protein aggregation have been linked to several neurodegenerative
disorders, but the exact mechanisms and causal connections are not clear and most …
disorders, but the exact mechanisms and causal connections are not clear and most …
[HTML][HTML] Structural insights into amyloid oligomers of the Parkinson disease-related protein α-synuclein
The presence of intraneuronal deposits mainly formed by amyloid fibrils of the presynaptic
protein α-synuclein (AS) is a hallmark of Parkinson disease. Currently, neurotoxicity is …
protein α-synuclein (AS) is a hallmark of Parkinson disease. Currently, neurotoxicity is …
Differential scanning calorimetry as a tool to estimate binding parameters in multiligand binding proteins
The stability of proteins and their interactions with other molecules is a topic of special
interest in biochemistry because many cellular processes depend on that. New methods and …
interest in biochemistry because many cellular processes depend on that. New methods and …