The ability to predict local structural features of a protein from the primary sequence is of
paramount importance for unraveling its function in absence of experimental structural …

We comprehensively assessed the contribution of the Shine-Dalgarno sequence to protein
expression and used the data to develop EMOPEC (Empirical Model and Oligos for Protein …

The accurate structural modeling of B- and T-cell receptors is fundamental to gain a detailed
insight in the mechanisms underlying immunity and in developing new drugs and therapies. …

Recombineering and multiplex automated genome engineering (MAGE) offer the possibility
to rapidly modify multiple genomic or plasmid sites at high efficiencies. This enables efficient …

Identifying the specific human leukocyte antigen (HLA) allele combination of an individual is
crucial in organ donation, risk assessment of autoimmune and infectious diseases and …

The global SARS-CoV-2 pandemic caused significant social and economic disruption
worldwide, despite highly effective vaccines being developed at an unprecedented speed. …

Background The B-cell lymphoma-extra-large (Bcl-XL) protein plays an important role in
cancer cells’ resistance to apoptosis. Pre-clinical studies have shown that vaccination with Bcl-…

The human leukocyte antigen (HLA) system is a group of genes coding for proteins that are
central to the adaptive immune system and identifying the specific HLA allele combination of …

Flow-seq combines flexible genome engineering methods with flow cytometry-based cell
sorting and deep DNA sequencing to enable comprehensive interrogation of genotype to …

Introduction Immunotherapy has revolutionized modern cancer treatment, both within the
fields of solid and haematology malignancies. The recent success of checkpoint inhibitor (CPI) …