Immune checkpoint inhibitors (ICIs) produce durable responses in some melanoma patients,
but many patients derive no clinical benefit, and the molecular underpinnings of such …

Neoantigens, which are derived from tumour-specific protein-coding mutations, are exempt
from central tolerance, can generate robust immune responses 1 , 2 and can function as …

The scale and capabilities of single-cell RNA-sequencing methods have expanded rapidly
in recent years, enabling major discoveries and large-scale cell mapping efforts. However, …

Type 2 innate lymphoid cells (ILC2s) both contribute to mucosal homeostasis and initiate
pathologic inflammation in allergic asthma. However, the signals that direct ILC2s to promote …

Both intrinsic cell state changes and variations in the composition of stem cell populations
have been implicated as contributors to aging. We used single-cell RNA-seq to dissect …

Stroma is a poorly defined non-parenchymal component of virtually every organ with key roles
in organ development, homeostasis, and repair. Studies of the bone marrow stroma have …

Genome sequencing studies have shown that human malignancies often bear mutations in
four or more driver genes 1 , but it is difficult to recapitulate this degree of genetic complexity …

Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of
haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly defined in …

Reversing the dysfunctional T cell state that arises in cancer and chronic viral infections is
the focus of therapeutic interventions; however, current therapies are effective in only some …

The expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a
key mechanism for ensuring immune homeostasis. Dysregulated expression of co-inhibitory …