Recent studies have expanded our knowledge, at the molecular level, of how myelin
inhibits axonal regeneration after injury to the mammalian central nervous system. Several …

The failure of axons to regenerate after spinal cord injury remains one of the greatest
challenges facing both medicine and neuroscience, but in the last 20 years there have been …

The lack of axonal growth after injury in the adult central nervous system (CNS) is due to
several factors including the formation of a glial scar, the absence of neurotrophic factors, the …

… CHO cells expressing an abundance of another myelin protein, PO (Filbin and Tennekoon
… once with dH*O before being mounted with Gel-mount and viewed with a Zeiss fluorescence …

Central neurons regenerate axons if a permissive environment is provided; after spinal cord
injury, however, inhibitory molecules are present that make the local environment …

Myelin inhibitors, including MAG, are major impediments to CNS regeneration. However,
CNS axons of DRGs regenerate if the peripheral branch of these neurons is lesioned first. We …

Myelin inhibitors of axonal regeneration, like Nogo and MAG, block regrowth after injury to
the adult CNS. While a GPI-linked receptor for Nogo (NgR) has been identified, MAG's …

Unlike neonatal axons, mammalian adult axons do not regenerate after injury. Likewise,
myelin, a major factor in preventing regeneration in the adult, inhibits regeneration from older …

MAG is a potent inhibitor of axonal regeneration. Here, inhibition by MAG, and myelin in
general, is blocked if neurons are exposed to neurotrophins before encountering the inhibitor; …

Background: Protein–carbohydrate interactions are believed to be important in many biological
processes that involve cell–cell communication. Apart from the selectins, the only well-…