Transcription is a stepwise process that involves many specialized proteins and protein
complexes, all of which must work together to express a given gene in a spatially and temporally …

The Drosophila insulin receptor (dInR) regulates cell growth and proliferation through the
dPI3K/dAkt pathway, which is conserved in metazoan organisms. Here we report the …

Transcription and DNA repair are coupled in E. coli by the Mfd protein, which dissociates
transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of …

To determine the prevalence of cotranscriptional splicing in Drosophila, we sequenced
nascent RNA transcripts from Drosophila S2 cells as well as from Drosophila heads. Eighty-…

Skeletal muscle differentiation requires a cascade of transcriptional events to control the
spatial and temporal expression of muscle-specific genes. Until recently, muscle-specific …

Uninduced heat shock genes are poised for rapid activation, with RNA polymerase II (Pol II)
transcriptionally engaged, but paused or stalled, within the promoter-proximal region. Upon …

Activator-dependent recruitment of TFIID initiates formation of the transcriptional preinitiation
complex. TFIID binds core promoter DNA elements and directs the assembly of other …

In transcription initiation, the DNA strands must be separated to expose the template to RNA
polymerase. As the closed initiation complex is converted to an open one, specific protein-…

Gre proteins of prokaryotes, and SII proteins of eukaryotes and archaea, are transcription
elongation factors that promote an endogenous transcript cleavage activity of RNA …

Drosha is a type III RNase, which plays a critical role in miRNA biogenesis. Drosha and its
double-stranded RNA-binding partner protein Pasha/DGCR8 likely recognize and cleave …